| Object:Animal damage model, adopt our academy to be late to cure expert Zheng cherish virtuous clinical experience side Zheng of professor traumatology activate the lotion as treating medicines while being military while being famous through set up, treat through the traditional Chinese medicine part, it is influenced to damaging some musculature PGE2 , IL-6content that traumatology activates the lotion to observe Zheng, influence to damaging some musculature morphology. Traumatology activates therapeutical function and mechanism that the lotion damages to the acute soft tissue to probe into Zheng, and this traditional Chinese medicine preparation damages the function repaired on the acute soft tissue, offer the theoretical foundation for the fact that this medicine treats the acute soft tissue to damage clinically.Method:96 male SD rats are subjected to acute soft tissue injury divided into six groups: the blank control group (group A), the modle control group (group B),the"Diclofenac Sodium Enteric-coated Tablets"group(group C), the low dosage group of the experiment(group D),the average dosage group of the experiment(group E), the high dosage group of the experiment(group F).Each change dressings once at 8 o'clock every morning and 8 o'clock in the evening, use medicine every days in succession . Every 6 rats are killed on the 1th,3th,5th day after using dosage and establishing rats acute soft tissue injury model. SD rats with abdominal aortic blood collected, remove the test tube of blood into the corresponding backup,It explains and examines some PGE2 and IL-6 content in the musculature to adopt ELISA law to operate according to the reagent box strictly,Cut and fetch musculature 300mg to organize the even thick liquid damaging the centre position. it is regular to put in 10% of the formaldehyde solution , send and make paraffin wax stripping and slicing and organization and cut HE into slices to dye in time, organize morphology to observe under the mere mirror .Result:njury symptoms observation Zheng-type index observed Trauma three active dose groups and cream Voltaren group could promote damage local swelling, subcutaneous ecchymosis and subcutaneous bleeding dissipated, different Light microscopic observation: Zhengshishangkehuoluogao traumatology three dose group, Voltaren group of local soft tissue injury significantly reduced the inflammation, the repair of muscle fiber is also rapidly than the model control group group.Model control group in the local soft tissue content of PGE2 and IL-6 was significantly higher than control group,Zhengshishangkehuoluogao of three experimental dose group the first day of the injury, the third day, fifth day of soft tissue injury can significantly inhibit PGE2 and IL-6 in the increase, and the group with Voltaren group, no significant difference; However, Zheng-type traumatology three active cream Voltaren dose group and model group with the control group and blank group was significant difference.Conclusion:Both the"Diclofenac Sodium Enteric-coated Tablets"and the"ZSSKHLG"experiment dosage can can reduce the content of the PGE2 and IL-6 in the acute injuring haematoma rat model and .In addition,it also remarkably heal the tissue. |
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