The Relationship Between Plasma Aldostetrone And Inflammatory Factors Levels In Primary Aldosteronism

Objective: To investigate the levels of tumor necrosis factor alpha(TNF-a),interleukin-6(IL-6) and high-sensitivity C-reactive protein (hsCRP) in patients with primary aldosteronism(PA). Then to study the relationship between inflammatory and aldosterone levels.Methods: We recruited 93 PA patients and 67 essential hypertensive (EH) patients from January 2009 to December 2010 in Hypertension department of People's Hospital of Xinjiang Uygur Autonomous Region.The concentration of TNF-aand IL-6 were measured with radioimmunoassay (RIA); And the concentration of hsCRP were detected with immunoturbidimetry (ITM). Further, the TNF-a,IL-6 and hsCRP levels were compared in two groups and the possible relationship with other factors.Results (1) Compared with EH patients, the PA patients had higher systolic blood pressure(SBP), and lower 24h serum potassium, urinary potassium excretion higher; While plasma renin activity (PRA) were lower, serum aldosterone (ALD) levels were higher (P<0.05). (2) The bilateral PA patients in clinical features showed no significant difference with the patients with unilateral PA. But the unilateral PA showd lower PRA and higher aldosterone/plasma renin activity ratio(ARR) (P<0.05). (3) The concentration of TNF-αshowed no difference between EH and PA groups(P>0.05), but PA patients had lower levels of IL-6 and hsCRP (P<0.001).Compared of unilateral and bilateral PA, the unilateral PA had higher TNF-αlevels(P= 0.036); But no significant difference between the two groups (P>0.05).(4)Using Pearson correlation analysis in all subjects showed TNF-awas significantly associated with GLU (P<0.05); serum IL-6 and blood glucose(GLU), triglyceride(TC), PRA, ALD and ARR was significant correlation (P<0.05);and hsCRP were significant associated with the variables, such as body mass index(BMI), abdominal circumference, GLU, TC, total cholesterol (TG), PRA and ARR (P<0.05). IL-6 showed a remarkable correlation with ALD and ARR in total group(r=0.183,-0.331, P<0.01).Conclusion:Our results showed that PA patients and EH patients had the same levels of TNF-a, but lower IL-6 and hsCRP than EH patients. In the all patients, the level of IL-6 showed a remakble correlation with ALD and ARR; the level of hsCRP showed a negative correlation with ARR, and the positive correlation with PRA, the indicators of obesity and serum lipids.