| Objective To investigate the diagnostic value of diffusion weighted imaging in cervical cancer, and its feasibility in predicting treatment response of cervical cancer to concurrent chemotherapeutic.Methods 63 patients with cervical cancer were confirmed by pathology and 10 cases of healthy volunteers were included in this study. Conventional MRI and DWI were performed in 3T magnetic resonance scanner with the b value of 1000s/mm2 .37 patients who received neoadjuvent chemotherapy underwent conventional MRI and DWI follow up examinations at one week, four weeks and two months after the therapy initiated.Results Clinical stage(FIGO): Ib stage in 28 cases, IIa stage in 12 cases,IIb stage in 19 cases,IIIa stage in 2 cases,IIIb and IVa stage in 1 case. The mean ADC value of the cervical cancer was lower than that of the normal cervix, and the difference between the two groups was significant(p<0.001). The mean ADC value of IIa stage was lower than that of the other stages(p<0.001). The pretreatment ADC value of CR was significantly lower than that PR and SD. The percentage ADC chang of CR at the time of one week after therapy was greater than PR and SD group (p<0.05), and the percentage ADC chang of CR and PR group were greater than that SD at the time of four week and two months (p<0.05).Conclusion DWI help to differentiate normal cervix and cervical cancer, as a useful supplement to conventional MRI examination can help diagnosis and staging of cervical cancer. The ADC value analysised before and after treatment of cervical cancer will help to monitor response to treatment ,and has the potential in predicting the tumor response to chemotherapeutic Objective To evaluate the characteristics with in vivo proton magnetic resonance spectroscopy of cervical cancers, and to investigates diagnostic value of single voxel magnetic resonance spectroscopy in cervical cancers.Methods. 35 patients with cervical cancer and 6 cases of healthy volunteers were were examined in a whole-body 3.0 T clinical magnetic resonance scanner. Single voxel spectroscopy (SVS) was undertaken after identification of lesions on T2-weighted imaging. Of which 5 patients with cervical cancer after chemotherapy were examined again.Results MRS were performed successfully in 30 cases. There were Cho in all cervical cancer (30/30, 100 %), Cr in 27 cases(27/30, 90%), Lac in 4 cases(4/30, 13.3%) and there were Lip in 25 cases(25/30, 83.3%). After chemotherapy, 2 cases of tumor volume increase than before, Cho was higher than before, and one case of tumor regression, Cho and Lip were decreased, 2 cases were no significant change.Conclusion 3.0T magnetic resonance spectroscopy for cervical cancer provides a molecular lesion in vivo metabolism of a new means of using . Cho peak detection of cervical cancer during treatment may reflect the molecular changes in metabolism. |
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