The Study Of Hepatocirrhosis Etiology Changes Of 4737 Patients And Risk Factors For Esophageal Variceal Bleeding In Patients With Hepatocirrhosis

Objective To understand the current situation of liver cirrhosis, by analyzing characteristics and dynamics of gender, age, nationality in cases of liver cirrhosis.Materials and Methods Describe the trend of some indicators of liver cirrhosis,by collecting and analyzing the clinical data of 4, 737 hospitalized patients with cirrhosis, from 2002 to 2009, in the Affiliated Hospital of Ningxia Medical University.Result (1) From 2002 to 2009, the number of hospitalized patients with cirrhosis is 1866 in the first 4 years, 2871 cases in the next 4 years, an upward trend 0000, but compared with the total number of hospitalization in the same period, there is no significant increase in the proportion. (2) The proportion of hepatitis B liver cirrhosis is the highest in recent years. (3) The proportion of liver cirrhosis is downward trend, 80.27% in first 4 years, which dropped to 78.27%. The incidence of alcoholic cirrhosis and autoimmune hepatitis gradually increase (the ratio of alcoholic cirrhosis from 2.62% to 6.57%, the ratio of autoimmune cirrhosis from 0.48% to 3.67%). (4) The peak age of liver cirrhosis is 40 to 59. (5) The majority of patients is male, male to female ratio is 2.95∶1. Men are more than women in alcoholic cirrhosis and hepatitis B liver cirrhosis, the ratio of alcoholic cirrhosis is 83∶1, the ratio of hepatitis B liver cirrhosis is 3.08∶1, but in autoimmune, female patients is about 3.14 times of men patients. (6) Han patients is significantly more than hui patients, han-hui ratio is 6.89∶1, alcoholic cirrhosis is the most obvious.Conclusion (1) The proportion of hepatitis B liver cirrhosis is the highest, but decreased in nearly 8 years,the proportions of alcoholic cirrhosis and autoimmune cirrhosis has increased. (2) Liver cirrhosis was mainly in young and middle aged-based. (3) The majority of alcoholic cirrhosis and hepatitis B liver cirrhosis patients is male, the majority of autoimmune cirrhosis patients is female. (4) Han patients is significantly more than hui patients, that of alcoholic cirrhosis is the most obvious. Objective To analyze the related risk factors for gastroesophageal varices (GOV) bleeding in patients with hepatocirrhosis and portal hyperention,so as to provide a reference for clinical work.Materials and Methods Collected and analyzed the clinical data of 638 hospitalized patients with cirrhosis from 2002 to 2009. Among 638 patients,there were 286 patients with upper gastrointestinal hemorrhage.Results (1) The results of comparison between hemorrhage group and non-bleeding group is significantly in the portal vein, splenic thickness, the relative value of neutrophils, albumin, cholesterol, prothrombin time. The platelet of hemorrhage group is lower than that of non-bleeding group, child score is higher than non-bleeding group, but no significant difference between the two groups. (2) Portal vein diameter, spleen thickness, the relative value of neutrophils, prothrombin time are positively related to bleeding, albumin, cholesterol are protective factors for bleeding. Spleen thickness, the relative value of neutrophils, albumin are independent risk factors for gastroesophageal varices (GOV) bleeding. Three indicators to assess the role of the risk of bleeding: spleen thickness of > the relative value of neutrophils> albumin. (3) Portal vein diameter, spleen thickness, the relative value of neutrophils, prothrombin time are risk factors of the first gastroesophageal varices bleeding, albumin, cholesterol are protective factors for bleeding. Spleen thickness, the relative value of neutrophils, albumin are independent risk factors for gastroesophageal varices bleeding.Conclusion Portal vein diameter, spleen thickness, the relative value of neutrophils, prothrombin time are the risk factors of gastroesophageal varices bleeding, albumin, cholesterol are protective factors. These indicators reflect the risk of gastroesophageal varices bleeding to a certain extent, but lack of sensitivity and reliability because of many confounding factors, so several indicators need to be used simultaneously.