A Clinical Comprehensive Survey Of Non-motor Symptom In Patients With Parkinson's Disease After The Treatment Of Deep Brain Stimulation

ObectiveTo respectively evaluate and contrast analysis the non-motor symtoms of patients with Parkinson's Disease (PD) undergoing deep brain stimulation(DBS)therapy and simple drug treament, observe the motor function and non-motor symtoms improvement of DBS therapy on PDpatients.MethodsTwenty-five patients with PD were included in a paired design study. The patients were randomly divided into DBS and anti- Parkinson's medication control groups , surveied by a questionnaire-type. Motor fluctuation and dyskinesia assessment was by the Unified Parkinson Disease Rating Scale Partâ…¢; non-motor symtoms assessment included the Mini Mental State Examination (MMSE), Alzheimer's Disease Rating Scale Revised-Cognitive (ADAS-cog), Hamilton (HAMD) and the Center for Epidemiologic Studies Depression Scale (CES-D); Pittsburgh sleep quality index ( PSQI ), Fatigue Scale (NF) and Constipation Scale.ResultsCompared with the medication control group, significant benefit was obtained in motor manifestations(UPDRS section3, P<0.001) of the DBS group, and its PSQI, NF HAMD and CES-D (P<0.05), without MMSE,ADAS-cog and Constipation Scale .Correlation analysis showed that Motor function could impact the extent and frequency of depression. Conclusions In the accordance with our results, DBS significantly improved the motor function and depression, the quality of sleep important aspects with advanced PD.