| Objective Observe the Boxintong capsule clinical efficacy of treatment of coronary heart disease, angina and action mechanism for clinical of coronary heart disease, angina, improve the control effect of providing new way of thinking.Methods Diagnostic criteria will be based on the diagnosis of coronary heart disease, angina pectoris 40 patients with clinical patients were randomly divided into the treatment group and control group (each group contains 20 cases), the treatment group to wrestle the capsule orally, heart to heart bolus group the oral, musk, twelve weeks of treatment by random, positive drug parallel controlled clinical study design method. Treatment compared between the two groups after clinical curative effect, before and after the treatment of twelve channel electrocardiogram, lipid (6), nitric oxide (NO), plasma superoxide dismutase (SOD), interleukin 6 (IL-6) and C-c-reactive protein (CRP) and other indexes to change. The statistical analysis of the data, the effectiveness of the appraisal conclusion.Results Actual completed Boxintong group (19 cases), powerfully in 11 cases, effective 4 cases, improved in 3,1 case ineffective, with the total effective 94.736%; Musk protect heart pill group got 18 cases,5 cases in 9 cases, effective in 2 cases, invalid, improvement in 2 cases,88.88%, total effective compared between the two groups non-significance difference; On the improvement of the electrocardiogram, treatment group and control group differences are effective and a little; In improving blood lipid aspects of Boxintong significantly better in general, including general groups after treating heart LDL levels dropped significantly (P< 0.05), compared with controls (P< 0.05), there are significant differences; The treatment group and control group therapy of SOD and NO plasma levels were significantly degree compared rise, both NO obvious difference; IL-6 and CRP level when the drug, two groups of comparisons were significantly decrease; Including IL-6 levels dropped significantly, the results of the Boxintong pill than musk (P< 0.05). Safety observation, before and after the treatment between the two groups compared the non-significance difference of the human body, there were no obvious side effects.Conclusions Boxintong capsules can obviously improve symptoms in patients with coronary heart disease, angina, and in some respects and musk protect heart pill effect is fairly or better than the heart pill musk. Improving plasma, SOD content of nitric oxide (NO); Inhibits and reduce oxygen free radical generation; Reducing CRP and IL-6 level, rise to fight and improve the inflammatory response function; Improve lipid levels, especially to reduce low-density lipoprotein and improve high-density lipoprotein Lord; Dilating coronary artery and peripheral vascular diameter; For in the treatment of coronary heart disease, a new method provides a new drug, also should card tong Yang method of scientific treatment of coronary heart disease. |
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