Rearch On Serum Lp(a) And The Early Diagnosis Of Diabetic Nephropathy

Objective: To investigate the clinical significance of analysis of serum Lipoprotein(a)[Lp(a)] level in diagnosis of early diabetic nephropathy(DN).Methods: 118 cases of diabetes mellitus were divided into 3 groups according to 24-hour urinary albumin excretion rate(UAER): group A(patients without DN), 41, UAER<30mg/24h; group B(early DN), 39, 30mg/24h≤UAER<300mg/24h); group C(clinical DN), 38, UAER≥300mg/24h. 40 healthy volunteers were as control group(group D). The UAER and serum Lp(a) were tested in all cases. The results were analyzed with ANOVA and Linear correlation. Results: The serum Lp(a) level of group A, B, C was higher than that of group D(group A vs. D, P < 0.05,group B,C vs. D, P < 0.01), and was increasing with the progression of DN (group B vs. A, P < 0.01,group C vs. B, P < 0.05)。The level of Lp(a) of Group C and B were positive linear correlation with UAER(group A, r = 0.356 , P < 0.05;group B, r = 0.438 , P < 0.01).Conclusions: Serum Lp(a) level may be related with the lesion of DN, the analysis of Lp(a) would be one of the adjunctive methods in the diagnosis of the early stage of this disease.