Small Molecule Drug Targets' Research Of Congenital Heart Block (CHB)

Congenital heart block(CHB)is a complete atrioventricular block and this disease seriously endangers the health of children. It is estimated that affect 1 / 5, 500 pregnant women (50% fetal mortality) and 1 / 11, 000 newborns, and lead to those children need rely on pacemaker living. To research this disease related drug targets will accelerate drug development of the disease, and greatly promote the targeted therapy of CHB when it will better clarify pathology of CHB.This paper build the positive set directly related with congenital heart block and the candidate negative set of this disease. Two sets contain the information of gene and protein.Firstly, using text mining through network data platform to integrate more reliable information of CHB related proteins, then building a CHB related positive set.Secondly, by PubMed, OMIM databases finding the existence of association between CHB and atrioventricular arrhythmia, heart failure, the theoretical basis through reports that analyze complex diseases by associated with the diseases .By the DrugBank database in search for potential drug targets of CHB, then construct a candidate negative set of CHB. By semantic similarity calculation and comparison between the two sets genes, and the ENDEAVOUR, GENECODIS databases'data to prioritize genes ,it find 20 potential drug target proteins of CHB. We also have done the GO functional classification of the potential drug targets and enrichment analysis of MicroRNA and SNP. The result of this paper is predicted 20 potential drug targets of CHB. 20 drug targets'functional features focus on voltage-gated ion channel activity, transporter activity, signal transducer activity, ion transporter activity and ion channel activity; Genes of candidate negative genes enriched the largest pathway is (KEGG)04020 Calcium signaling pathway, then have(KEGG)04010 MAPK signaling pathway,(KEGG)05410 Hypertrophic cardiomyopathy(HCM).At the same time, MicroRNA(hsa-miR-770-5P)enriched in 15 genes of the candidate negative set.This study has a certain significance of of congenital heart block treatment and provides a basis for drug development of this disease.