| Objective To observe the influence of rosuvastatin on interleukin-8 (IL-8) and its expression in rabbit atherosclerosis model.Methods 30 New Zealand rabbits were randomly divided into three groups:control group (n=10), experiment group (n=10) and treatment group (n=10). Animals in control group received normal diet, the other two groups received arterial intimal injury of carotid with balloon after four weeks experiment feeding, then treated with experiment, experiment and rosuvastatin for six weeks, respectively.3 ml blood was drawn from the ear vein of all the rabbits after the carotid arterial intimal injury (at the end of the fourth week) and before sacrifice (at the end of the tenth week).Lipid and IL-8 levels were measured. At the end of the experiment, all rabbits were sacrificed, the carotid arteries were isolated and paraffin-embedded slices and immunohistochermical staining of IL-8 were performed.Results Compared with control group, Lipid and IL-8 levels in treatment group and experiment group were significantly increased at the end of 4 weeks (P<0.05), and lipid and IL-8 levels in treatment group were significantly lower than experiment group at the end of 10 weeks (P<0.05);There were no arteriosclerosis lesions and IL-8 expression in the carotid arteries of control group; Compared with experiment group, intima area(IA), ratio of intima area to membrane area (I/M), luminal stenosis degrees(LSD) and the expression of IL-8 on atherosclerotic plaque were significantly decreased in treatment group (P<0.05)Conclusion Rosuvastatin can reduce IL-8 level and decrease expression of IL-8 in atherosclerosis plaques. It demonstrates that rosuvastatin may inhibit the progression of atherosclerosis by reducing the inflammatory action. |
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