Tongxinluo Capsule Plasma Levels Of Ang-2 And 6-Keto-PGF1a Level Of The Metabolic Syndrome

Objective:To investigate the effect of bisoprolol with different time on blood pressure control and circadian variability of dipper blood pressure for patients with Non-dipper hypertension and renin-angiotension-aldosterone system.Methods:60 cases with Non-dipper hypertension were chosen form in-patient and out-patient between November 1,2008, and September 1,2010. All the patients ceased to take antihypertensive drug before the study for a week. The patients were randomly divided into two parallel groups. All patients were treated with bisoprolol. The first group took bisoprolol at eight o'clock once-daily between 2.5mg and 10mg. The second group took bisoprolol at twenty o'clock once-daily between 2.5mg and 10mg. The efficiency of the 8 weeks' treatment and the change of the 24 hours blood pressure and the concentration of renin,angiotension and aldosterone were detected.Results:(1)The blood pressures of the patients in both groups decreased (p<0.05). And there was no significant difference between the two groups for the day BP decrease (P>0.05), but taking bisoprolol at first group had a better efficacy than that in the second group of the ninght BP. (2) On the recovery diurnal rhythm of blood pressure the first group was better than that of second group (p<0.05). There were 10 hypertensive patients with non-dipper pattern of blood pressure changed into dipper pattern in the first group while there were 19 patients changed in the second group. There were no significant effects on liver and kindey function of the two groups. Both groups can obviously lower concentration on renin,angiotension and aldosterone after treatment (p<0.05). And there is no significant difference between the two groups on the concentration of renin (P>0.05), but a significant on angiotension and aldosterone.3 adverse events were occurred in the course of the research, the incidence of adverse events of the two groups has no significant difference.Conclusion:Two menthds of treatment can control the blood pressure safe and efficacy, but taking drug at eight o'clock was better for the Non-dippers Hypertension and the the diurnal rhythm of blood pressure than taking at twenty o'clock.