| The collagen mimetic peptide with a repeated X-Y-G sequence couldself-assemble to triple helices homotrimers. With other forces, it underwenthigher level of self-assembly. In this paper, a new type of collagen mimeticpeptide,(PKG)n(POG)2n(DOG)n, which n=1,2, with charged-domain ends hadbeen designed and successfully prepared. Circular dichroism (CD) spectrawere performed to verify the formation of triple-helical structure of thesynthesized peptide. The collagen-like homotrimers underwent higher level ofself-assembly via static electrical interaction between positive and negativedomains. Transmission electron microscope (TEM) examinations showedthree typical morphologies of homotrimer assembly, which were defined asfilm, bicontinuous and fibril morphology in this paper. For the length ofpeptide homotrimer was short, film was formed in the initial stage like theliquid crystal film. But the film morphology was not very stable. When theenergy of system increased, the homotrimer structure unit trended to changeorientation and transform to bicontinuous morphology, or curl to fibrils toimprove stability of the assemblies or decrease surface energy.According to the new study about treating dentin hypersensitivity,mesoporous silica nanoparticles performed better effect than traditionalmaterials. This kind of material was purposed to block the dentin tubule inorder to prevent from outside stimulation. Using CTAB as the organictemplate, a highly ordered MCM-41mesoporous silica nanoparticle wasprepared by self-assembly. Nano-CaCl2and nano-phosphoric acid wereencapsulated in the mesoporous silica nanoparticles and showed as whitepowders. The two kinds of powders were mixed with deionized water in aproper ratio. When the toothpaste-like mixture was daubed on the surface oftooth sample several times, it could reach a more than110nm depth and solidified by forming calcium phosphates. And then the dentin tubule wasblocked. |
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