Applications Of The Organic-inorganic Hybrid Silica In Enantioseparation

In recent decades, the chromatographic separation of enantiomers, in particular, theHPLC method has been excellent development. It is a simple and rapid approach foranalysis and preparation of chiral compounds using HPLC. The forefront of thedevelopment of chiral chromatography is to prepare stationary phase (SP) withasymmetric center. Firstly, bissilsesquioxanes were synthesized using L-isoleucine andL-Phe as the start materials. Secondly, chiral stationary phases were prepared bygrafting these amino acid derivatives on the surfaces of the mesoporous silica spheres. Itwas found that the chiral SP can separate some amino acid derivates and BINOL.Moreover, a chiral SP was prepared by grafting a phenylglycine derivate on the surfacesof the mesoporous silica spheres, which can separate a series of aromatic compounds.Optically active polymers can be applied for enantioseparation and asymmetriccatalysis. Their structures play important roles on their physical and chemical behaviors.Herein, two chiral polymers derived from valines were prepared through astructural-directing approach. The monomers self-assembled, firstly. Then, the polymerswere obtained after polymerization under UV. The obtained samples were characterizedusing scanning electron microscopy and FT-IR.