Synthesis, Characterization, And Properties Of Schiff-base Porphyrins

In recent years, porphyrin compounds have drawn much attention for their strong absorption in visible spectra and good photothermal stability in the field of dye-sensitized TiO2. Compared to the pure TiO2, the catalytic activity of TiO2will get stronger and the absorption efficiency will enhance after sensitized by porphyrin compounds according to many researches on disposing of water pollution.In addition, much attention have been payed on the research of the application of porphyrin compounds as anti-cancer drugs. New composite anti-cancer drugs will be obtained by carrying anticancer moleculars with porphyrin compounds on account of their preferential assembling on tumour cells. Meanwhile, the porphyrin compounds also have anti-cancer activities under illumination, therefore, the new composite anti-cancer drugs not only have good selectivities, but also can enhance anti-cancer activities.The Sciff base compounds have pharmacodynamic and physiologic activities. They can well inhibit the super oxygen cation, thus, they exhibit anticancer and antibiosis effects. Compared to the drugs with single component, the composite system with both porphyrin and Sciff base by bonding Sciff base with porphyrin has better anticancer effect.In view of the above reasons, one porphyrin with aldehyde group(P1) and two porphyrins with Sciff base groups, P3) were synthesized. Moreover, three porphyrin compounds with aldehyde group based on Cu(â…¡), Zn(â…¡), Co(â…¡)(CuP1, ZnP1, CoP1) and one porphyrin compound with oximido group based on Cu(â…¡)(CuP2) were also obtained. They were all characterized by elemental analysis, FT-IR, UV-Vis, MS and1H-NMR.Two composite photocatalysts of porphyrin-TiO2with copper porphyrin as photosensitizer(CuP1-TiO2, CuP2-TiO2) were prepared and characterized by SEM, DRS, XRD and FT-IR spectroscopy. The degradation effects of the two catalysts on4-NP were determined and compared with CuTPP-TiO2-The factors that influence the catalytic efficiency, such as The adsorption between TiO2and porphyrin compounds with different substituent groups and the dispersibility of the catalysts, were discussed.Moreover, the anticancer activities of the three porphyrin moleculars(P10, P2, P3) on A431cell were studied and the abilities of producing singlet oxygen were determined by the degradation measurement of DPBF. The results revealed that porphyrin with Sciff base group(P2, P3) not only showed good anticancer activities, but also had good selectivities.