Aliphatic-Aromatic Amide Hybrid Foldamers:Synthesis, Characterization And Recognition Property

Supramolecular chemistry has been defined as "chemistry beyond the molecule". It aims at constructing highly complex, functional chemical systems from components held together by intermolecular noncovalent forces. Inspired by the functions and complicated structures of biologic macromolecules, innumerable "supermen"(supramolecular chemists) are trying to develop artificial foldamers for mimicking and understanding the mechanisms and inherent principles between advanced structures and functions in the nature. Due to the enormous possibility of augmenting the conformational space available for oligomer design, the hetero foldamer approach has been introduced very recently. This thesis focuses on the disign and study of aliphatic-aromatic hetero foldamers that bear D-camphoric acid or amine as building blocks.In the first section, we have tried to prepare aliphatic-aromatic imine macrocycles using D-camphoric amine as building block. The targeted macrocycle product has been detected by MS, but we haven’t gained them after several attempts due to the instability of the product.In the seond section, we have successfully prepared a series of aliphatic-aromatic hetero foldamers that bear D-camphoric acid or amine as "turn". The crystal structure of one of them indicates that the hetero foldamer displays a helical configuration due to the D-camphoric amine "turn".In the third section, we have given a preliminary demonstration that meta-substituted benzamide oligomers can fold to complex tricarboxylate anions in DMSO by NMR and CD measures.