A Cases-analysis Study On The Relationship Between Plasma High Sensitivity C-reactive Protein （hs-CRP）and Acute Iskemic Stroke

Objective:To study the relationship between plasma high sensitivityC-reactive protein （hs-CRP）and acute iskemic stroke，as well as that of hs-CRP andatherosclerosis.Method:We retrospectively analyzed the data of120acute ischemic stroke patientswho were admitted in the first Affiliated Hospital of Fujian Medical University fromJune2011to December2011and collected41health individuals as concurrent controlgroup.We documented the patients’ serum high sensitivity C reactive protein andblood lipid，as well as the results of carotid atery B-ultrasonography and magneticresonance imaging/angiography （MRI/MRA） or CT scanning/CT angiography（CT/CTA）.The statistical analysis was performed by using SPSS17.0.Results:A significant different level of serum hs-CRP was found between the stokegroup and the concurrent control group (Z=-6.579,p=0.000).Hs-CRP showedpositive correlations with NIHSS score,plasma fibrinogen,carotid plaque propertitesand the maximum diameter of infartion area on MRI or CT images,and the naturallogarithm value of hs-CRP showed a linear relationship with the relavent factors asdescribed above in the anterior circulation infarct group.While in the posteriorcirculation infarct group,different relavent factors were seen to have a linearrelationship with the natural logarithm value of hs-CRP,which were glycatedhemoglobin and fibrinogen.Conclusion:High sensitivity protein was in a close relationship with acute ischemicstroke and atherosclerosis.Different linear relationships with the natural logarithmvalue of hs-CRP were seen between the anterior and posterior circulation infarctgroup.