The Relationship Of Functional Dyspepsia With Motilin And Calcitonin Gene-related Peptide In Gastric Mucosa

ObjectivesTo investigate the relationship of functional dyspepsia with motilinand calcitonin gene-related peptide in gastric mucosa.MethodsThere are50Patients with functional dyspepsia,diagnosed accordingto Rome Ⅲ Criteria, and42healthy controls were enrolled in this study.Comparing the variables of the two groups and the subgroups of functionaldyspepsia patients, including the content of motilin and calcitoningene-related peptide in gastric mucosa. ELISA was used to detect thecontent of motilin and calcitonin gene-related peptide,and then useIndependent two-sample t-test for statistical analysis.ResultsThe results showed that the motilin and calcitonion gene-relatedpeptide content of gastric mucosa in functional dyspepsia patients wassignificantly lower than that in healthy controls(P<0.05)，the level ofmotilin and calcitonion gene-related peptide content of gastric mucosain subgroups of functional dyspepsia patients was no difference.Conclusions1. The decreased motilin content of gastric mucosa in functional dyspepsiamay be involved in the pathogenesis of FD.2.The decreased calcitonion gene-related peptide content of gastricmucosa in functional dyspepsia may be involved in the pathogenesis of FD.