Correlation Between Cognitive Impairment After Acute Stroke And Surem Neuron Specific Enolase,C-reactive Protein

[Objective] Cognitive impairment is a common complication after acute stroke. Currently, the diagnosis of cognitive impairment is basically determined by intelligence scale, lacking of appropriate serological maker. So to explore the correlation between the occurrence and severity of cognitive impairment after stroke and serum NSE and CRP level, and to combine the MMSE with the serum markers can improve the accuracy of clinical diagnosis of cognitive impairment after stroke, analyzing its possible causes, and can provide clinical basis for early prediction and early intervention of the disease.[Methods] After the assessment of the cognitive function by Mini Mental State Examination (MMSE),92patients with acute stroke were devided into two gropes:Cognitive Impairment group and non-Cognitive Impairment group, And the concentrations of NSE and CRP were measured by ELISA and immunoturbidimetry at3-5days after onset of fasting in patients, and then the result compared with20controls.[Results] Serum NSE and CRP level in patients with acute stroke were higher than the control,(P<0.05); and the level of Serum NSE and CRP in cognitive impairment after stroke were higher than those in non-cognitive impairment after stroke group,(P<0.05). There was a significantly negative correlation among serum NSE and CRP and the MMSE score of cognitive impairment after stroke.[Conclusion] Cognitive impairment after acute stroke were closely related with serum NSE and CRP level, which can reflect the degree of cognitive impairment in patients with stroke. So combined with MMSE, testing serum NSE and CRP level as a biological test indicators of cognitive impairment after stroke can be a diagnostic maker to provide clinical basis for early detection and early treatment of the disease. Additionally, there may be a relationship between congnitive impairment and the location and area of stroke, but the former may be important. So there should be further study due to the fewer number of cases.