The Applications Of The OCT Scanning Devices For Imaging In Vivo Tissues

Optical Coherence Tomography(OCT)is a rapidly developed medical imaging method in recent years. It has the advantages of high resolution、non-invasive、non-contact and real-time imaging.OCT which is based on the low coherence interference is able to detect the internal structure of in-vivo tissues. It hasbeen widely applied in medical fields such as dentistry、dermatology、ophthalmology.OCT has become a new branch of medical imaging field and has broad application prospects.With the imaging of the in vivo tissues, OCT has important theoretical and practical significance for clinical diagnosis. Based on the principle of the OCT system and the previous work of the laboratory, the main work of the thesisare as follows:1、The lateral scanning device of the OCT system has been studied. The mechanical structure of the OCT scanning device based on the MEMS probe is designed. Two different OCT probes for in vivo tissue imaging has been made.2、The optical structure of the OCT system has been designed. The scanning path of the MEMS probe has been studied. An algorithm has been proposed tocorrect the image acquired by the MEMS probe.3、Based on the principle of the MEMS probe, the data acquisition and processing program has been developed. The control and display of the system is also successfully completed. With this system, the images of some different samples are acquired.4、The image of the in vivo dental and human skin has been successfully acquired. A new theoretical description of the OCT technique for use in imaging in vivo tissues based on the extended Huygens-Fresnel principle has been introduced. Through the fit of the heterodyne signal expression to the OCT axial signal curve, the scattering coefficients of dental and skin are acquired. It is demonstrated that OCT is a feasible method for imaging of in vivo tissues.