The Case-control Study On Relationship Between Metabolic Syndrome And Prostate Cancer·

Objective:Observe and analyse the difference in the incidence of metabolic syndrome among the prostate cancer patients of Han population in Guangdong district and the normal healthy people, also analyzing the influence that metabolic syndrome and its components bring to the incidence of prostate cancer, at the same time comparing the relationship between prostate-related indicators and metabolic syndrome incidence.Methods:208cases of prostate cancer patients were selected from the First Affiliated Hospital of Jinan University, whose diagnosis was lasted from March2007to March2012. And210cases of healthy subjects from the same hospital at the same period as control group. Collect the data of the indicators of prostate cancer patients with blood pressure, blood glucose, height, weight, PSA values, pathological type, gleason score, and prostate size, et al.All the patients’blood indices which related to the metabolic syndrome were fasting venous blood in the morning, the other indicators were measured with the corresponding method. The data is collected for statistical analysis.Results:When the prostate cancer group compared with the healthy people group, the body mass index (BMI), blood pressure (BP), blood sugar (BS), triglyceride (TG), low-density lipoprotein (LDL) were increased, but high-denstiy lipoprotein decreased, the difference was statistically significant (P<0.05). MS incidence was statistically discrepancy. Logistic regression analysis of the risk of prostate cancer, tick variable at a=0.05level. The high triglycerides, low HDL, high LDL, high blood sugar and prostate cancer show a positive correlation (P=0.000, OR=2.91,95%CI:1.612-5.241; P=0.000, OR=7.89,95%CI:3.908-15.947; P=0.015,OR=1.87,95%CI:1.131-3.077; P=0.004, OR=2.17,95%CI:1.280-3.686). Their correlations were statistically discrepancy. The number of metabolic syndrome’s components and prostate cancer showed a positive correlation (P=0.000,OR=1.90,95%CI:0.107-10.629). Age, prostate volume and residual urine increasing show a positive correlation with MS (P=0.000, OR=1.10; P=0.000, OR=1.04; P=0.000, OR=1.02). It has higher gleason score, earlier tumor metastasis and higher immunohistochemical P504S positive rate in group of prostate cancer diagnosed as MS than those diagnosed as non-MS. The risk factors for prostate cancer metastasis logistic regression analysis, tick variable at α=0.05level. The results show that the degree of gleason score has positive correlation with prostate cancer metastasis, but age with negative correlation.Conclusion:The prevalence rate of metabolic syndrome in prostate cancer patients is significantly higher than healthy people, and the prostate volume of metabolic syndrome patients is increased.The metabolic syndrome is one of the risk factors for prostate cancer, with the increasing of the number of the various components of metabolic syndrome, the risk of prostate cancer increased.Among the various components of metabolic syndrome, TG, LDL and high blood sugar are the risk factors for prostate cancer, and HDL as the protective factor. However, the correlation between obesity, hypertension and prostate cancer remains to be further studied.Prostate cancer patients with concurrent MS have a higher gleason score and be more prone to metastasis.