Effects Of Anemia On Dosage Of Tacrolimus And Renal Function Of Posttransplant Recipients

Objective To retrospectively study and analyse the effects of anemia on the concentration anddosage of tacrolimus and renal function of posttransplant recipients and to show the importance ofcorrection of anemia and provide a reference for clinical..Methods The patients of47were divided as anemic and non-anemic groups,who received renaltransplantation at The Urology Surgery of The first affiliated hospital of Jinan University in theperiod between2008and2011.The anemia was a haemoglobin concentration of (men Hb＜120g/Lor women Hb＜110g/L） within3months after renal transplantation.（1）Compared the tacrolimusconcentrations in whole blood,the dosage of tacrolimus and serum creatinine,serum ureanitrogen,serum creatinine clearance between the two groups at the points of1st week,2nd week,3rdweek,4th week,8th week,12th week after renal transplantation.（2）Monofactorial correlationanalysis was used to determine the relationship of serum creatinine,serum urea nitrogen,serumcreatinine clearance with haemoglobin concentration to detect the effects of anemia on transplantrenal function.Results （1）Comparison showed no significant difference in the tacrolimus concentration in wholeblood between anemic and non-anemic group（P＞0.05）;but the dosage of tacrolimus in anemicgroup was significantly greater than in non-anemic group（P＜0.05）（.2）Compared to non-anemicgroup,the serum creatinine and the serum urea nitrogen of anemic group were significantly higher（P＜0.05）;the serum creatinine clearance was significantly lowe（rP＜0.05）（.3）Between two groups,serum creatinine and serum urea nitrogen were both significantly negative correlated withhaemoglobin（r=-0.872，P＝0.023; r=-0.860，P＝0.028）; serum creatinine clearance wassignificantly positive correlated with haemoglobin（r=0.922, P＝0.009）.Conclusions (1) The recipients after renal transplantation no matter there is anemia could attainthe tacrolimus concentration in whole blood to the therapeutic window; the anemic recipients neededa greater dosage and had a higher risk of side effects than non-anemic recipients.(2) It is importantto pay more attention to the active treatment of anemia after kidney transplantation, which ensuresthe safe use of tacrolimus and the good prognosis.