Dual Echo Chemical Shift Imaging And ~1H-MRS In The Diagnosis Of Fatty Liver Disease

Objective: Analyzed the feature of diffuse fatty liver’s proton magneticresonance spectroscopy(1H-MRS) and Dual echo chemical shift imaginggraphic, investigated the relationship between the area of lipid peak、the areaof water peak and fatty liver, and the relationship between signal intensitychange of liver on in-phase, out-of-phase and fatty liver, then explored theapplication of MRS and Dual echo chemical shift imaging in quantitativeanalysis in the value of liver fat content.Materials and Methods：Screening 40 patients with diffuse fatty liverand 20 health volunteers by Ultrasonography, and recorded age, body height,body weight and the biochemical indicators, all normal control and fatty livergroup under went regular T1WI, T2WI and Dual echo chemical shift imaging,proton magnetic resonance spectroscopy(~1H-MRS)。Then the signal intensityon in-phase and out-of-phase were measured, hepatic fat fraction(HFF) werecalculated, the area of lipid peak and the area of water peak by~1H-MRS weremeasured, relative lipid content(RLC) were calculated. Statistics softwareanalysis the correlation between Dual echo chemical shift imaging, protonmagnetic resonance spectroscopy(~1H-MRS) in the quantitative liver fatcontent.Results: The all spectrum curve results of~1H-MRS were in accordingwith the results of ultrasonography. No fatty liver group had two cases onlyappeared water peak, the other 18 cases all appeared little and low of lipidpeak, 40 cases of fatty liver group except water peak, also appeared with the lipid peak which a relatively water peak short and broad. The area of waterpeak has not obvious difference between these normal control and fatty livergroup(P＞0.05)；but the area of lipid peak has obvious difference betweenthese two groups(P＜0.05); Normal control liver signal intensity has notobvious difference between in-phase and out-of-phase(P=0.068); fatty liverpatients liver signal intensity has obvious difference between in-phase andout-of -phase(P＜0.05); Liver signal intensity hasn’t obvious differencebetween normal control and fatty liver group (P=0.634); on out-of-phase liversignal intensity has obvious difference between normal control and fatty livergroup(P＜0.05); proton magnetic resonance spectroscopy(1H-MRS) in thequantitative liver fat content has obvious difference(P＜0.05), Dual echochemical shift imaging calculated hepatic fat fraction(HFF) has obviousdifference(P＜0.05).Spearman analysis proton magnetic resonance spectroscopy(1H-MRS)calculated relative lipid content(RLC) showed statistically significant positivecorrelations with AST(r=0.305)、TG(r=0.317)(P＜0.05), and no correlationswith age, BMI, ALT, TC, HDLC, LDLC, VDLD.Spearman analysis dual echo chemical shift imaging calculated hepaticfat fraction(HFF) showed statistically significant positive correlations withVLDL(r=0.331)(P＜0.05), and no correlations with age, BMI, ALT, AST, TG,TC, HDLC, LDLC.Conclusions:MRI Dual echo chemical shift IP/OP can be better toidentify fatty liver, the two are complementary and without anyone are not.The intrahepatic content of lipid can be acquired by1H-MRS, which might behelpful to the diagnosis of fatty liver.