Clinicopathological Analysis Of89Cases With Gastrointestinal Stromal Tumors

Objective:To investigate the relationship and evaluation of the clinicopt logical characteristics and risk classification of gastrointestinal stromal tumor (GIST)Methods:1. The clinical characteristics, pathomorphology and immunohis tochemical sults of89cases of patients with gastrointestinal stromal tumor were analyzed retrospectively.2. All of the GISTs cases were graded by The National Institutes of Health (NIH) grading criteria.Rusults:1. Most of patients age ranges from50to60years (means54.4±11.9years), male to female was1.1to1. The tumors situated in gastrointestinal tract accounted for77.53%. Abdominal pain and alimentary tract hemorrhage were the main symptoms of the GISTs.2. The most common cell type was spindle cell which accounted for67.4%. The clinicopathological characteristics (gender, age, clinical symptom, histology type) of GIST were not correlated with the risk criteria (p>0.05).3. The positive rates of DOG-1, CD117, CD34, NSE and SMA expression were98.9%(88/89),95.5%(85/89),71.9%(64/89),59.6%(53/89) and31.5%(28/89), respectively. The positive rates of DOG-1was100%in the cases which did not express CD117. No significant difference was found in the expressions of the above all immunohistochemical markers among the different risk classification groups, relapsing and metastatic groups (p>0.05).4. The risk classification of single group was higher than the combined group (p<0.01). The patients with recurrence and metastasis were all the high risk classification groups (p<0.01).Conclusions:1. The clinicopathological characteristics (gender, age, clincal symptom, histology type) of GIST and the expressions of CD117, CD34, DOG-1, NSE and SMA are all not correlate with the risk classification, respectively, however, are important for diagnosis and differential diagnosis.2. The Patients with the recurrence and metastasis are higher than no-recurrence and no-metastasis groups, which showed that the higher risk-grading is, the greater chance there is to recurrence and metastasis.