The Changes And Significance Of Serum8-OHdG And MnSOD In Patients With Type2Diabetes And Obstructive Sleep Apnea Hypopnea Syndrome

Objectives:1. To observe the changes of serum8-hydroxy-guanine(8-OhdG) and serum manganese superoxide dismutase (MnSOD) in the patients with obstructive sleep apnea-hypopnea syndrome (OSAHS), type2diabetes mellitus and OSAHS with type2diabetes mellitus,(T2DM) in order to explore the role of8-OhdG and MnSOD in OSAHS in the high incidence of T2DM possible mechanism.2. To analyze the changes and significance of treatment with nasal-continuous positive airway pressure (nCPAP) on8-OhdG, MnSOD, apnea-hypopnea index (AHI), low arterial oxygen saturation(LSaO2), mean arterial oxygen saturation(MSaO2)and fasting plasma glucose(FPG)of OSAHS withT2DM (20cases)Methods:1.The subjects underwent overnight (about7hours) polysomnography. They were divided into four groups according to diagnostic criteria of OSAHS and T2DM:28cases of OSAHS(group O),28cases of OSAHS with T2DM(group OD),28cases of T2DM (group DM), and28cases of control people(group N).2.The serum8-OHdG levels were measured with ELISA in all of the subjects. The serum MnSOD levels were measured with Xanthinoxidase method.3.After1month of nasal-continuous positive airway pressure (nCPAP) therapy in OSAHS with T2DM patients(20cases), the PSG,8-OHdG and MnSOD levels were reviewed in the last day.Results:1.The serum levels of8-OHdG were higher compared with the control group(P<0.05),the serum levels of MnSOD were lower compared with the control group, and the serum levels of8-OHdG of OSAHS with T2DM was the highest, the serum levels of MnSOD was lowest (P<0.05). The serum levels of8-OHdG in group O were higher between group O and group DM.(P<0.05). The serum levels of MnSOD in group O were lower between group O and group DM.(P<0.05).2.The serum levels of8-OHdG positively related with AHI, FPG(P<0.05), and negatively with LSaO2and MSaO2(P<0.05); The MnSOD levels positively related with LSaO2, MSaO2(P<0.05), and negatively with AHI and FPG(P<0.05).3.There was a decrease in8-OHdG and an increase in MnSOD concentrations (P<0.05) in OSAHS with T2DM after nCPAP therapy;And FPG levels were lower(P<0.05).Conclusions:1.Intermittent hypoxiais one of the risk factors caused by the oxidative stress of patients with OSAHS 2.High incidence of T2DM in patients with OSAHS and oxidative stress has a certain association3.The body’s oxidative stress in patients with OSAHS extent has a certain association with low oxygen levels and fasting plasma glucose.4.nCPAP therapy can reduce the occurrence of oxidative stress, delay the development of T2DM in OSAHS concurrent.