The Contrast Of Curative Efficacy Between Subclavian Artery Infusion And Conventional Venous Chemotherapy With Pirarubicin In Locally Advanced Breast Cancer

Objective:To study the best way of neoadjuvant chemotherapy in locallyadvanced breast cancer.Methods：Selecting58cases of breast cancer（stageⅢ） patients treatedin breast surgery，china-japan union hospital of jilin university，in November2009-November2011.All patients were randomly divided into two groups,including27cases of subclavian artery infusion groupe and31cases ofsystemic intravenous chemotherapy group.Both groupes took neoadjuvantchemotherapy mainly containing Pirarubicin.The chemotherapy drugs and thedoses were for cyclophosphamide500mg/m2, Pirarubicin40mg/m2，5-Fu500mg/m2.The artery group took subclavian artery perfusion chemotherapy bySeldinger’s technique following percutaneous femoral artery puncture, fourweeks as a course of treatment.The vein group was performanced by Peripheralintravenous drip only once，three weeks as a course of treatment, mean2to4course of treatment.After chemotherapy observing the clinical efficacy and theside reaction of two groups, doing a comparative study.Results: The artery group was generally performanced preoperativechemotherapy for1to2courses of treatment，the vein group generally was for2to4courses of treatment.Though observation at two weeks afterchemotherapy，the tumor diameter of artery group reduced from7.08±1.34cmto3.83±1.22cm， while the tumor diameter of vein group reduced from7.15±1.41cm to5.19±1.19cm.The Clinical response rate in artery group was96.30%，while the vein group was41.94%.There was statistic difference between the two groups(P<0.05).Through observation before the operation，theClinical response rate in artery group was96.30%，while the vein group was90.32%，there was no statistic difference between the two groups(P>0.05). Thetime interval from Chemotherapy to operation in artery group was15.5士5.60days，while the vein group was60.10士16.34days，the former was obviouslyshorter than the latter. About the side effects of Chemotherapy，the bonemarrow inhibition and gastrointestinal reaction rate in artery group wassignificantly lower than the vein group，there was statistic difference betweenthe two groups(P<0.05).Conclusion: Subclavian artery infusion with Pirarubicin is a practical andeffective method of neoadjuvant chemotherapy for locally advanced breastcancer, compared with systemic venous chemotherapy, it can improve thesuccess rate of operation and the resection rate in locally advanced breastcancer patients, reduce systemic adverse reaction，early remove the tumor,prevent metastasis and recurrence.