Renal Outcomes Of Severe Acute Kidney Injury And Analysis Of Related Factors

Objective:Analysis the severe acute kidney injury (AKI) patients in intensive care unit (ICU) of our hospital admitted during2008March and2010Dec who need renal replacement therapy (RRT), understanding of the renal outcome of these patients and its related factors.Methods:Retrospective analysis the characteristics of concomitant and underlying diseases, sex distribution, age and RIFLE distribution of severe AKI patients, these patients were followed up to3months after starting RRT, and make a mutable analysis about the relationship of these factors with the kidney outcome of severe AKI patients.Results:In the151AKI patients, there are108patients alived to the3months aftrer starting RRT,16males and32females, the mean age is50, of which43patients associated with infection,27patients occurs AKI after surgery,11patients concomitance with hypovolemia,14patents caused by nephrotoxicity drugs,7patents are post-traumatic,5patients concomitance with hepatorenal syndrome. In this sample,30patients had hypertension,14patients had diabetes mellitus and5patients had chronic kidney diseases. Classificated by RIFEL criteria, the number of R level, I level, F level are21,30,47.86patients totally recover in renal function, the recovery rate is 79.63%. RIFLE levels (P＜0.001), age (P＜0.01), hypertension (P＜0.05), diabetes(P<0.05), chronic kidney diaeases (P<0.05) and use of nephrotoxicity drugs (P＜0.05)、concomitance with infection (P=0.391),correlate with kidney function recovery rate of severe AKI patients. Age, RIFLE level and chronic kidney diseases are independent risk factors for the kidney function recovery rate.Conclusion:Patients with severe AKI followed up by3months after the RRT, its renal function completely recover rate is about79.63%. The patients who are older, more serious renal function level, infection, had hypertension before, had chronic kidney disease before have a poor kidney outcomes, Age, RIFLE level and chronic kidney diseases are independent risk factors for the renal function recovery rate.