The Relationship Between Obesity And Prostate Cancer In Han Population

Objective:Use the body mass index to research the relationship between obesity and prostate cancer in Han population, including the association of BMI with age, blood PSA level, pathologic result, prostate volume.Method:From January2010to January2012,188consecutive patients who were treated with RP after the prostate needle biopsy in our department were reviewed retrospectively. We collected the data of these patients, including age, preoperative blood PSA levels, clinical stages, prostate volume, Gleason score of biopsy specimens and RP specimens and rate of extracapsular extension, seminal vesicle invasion, lymph node invasion, and tested the effect of BMI on these factors in univariate and multivariate logistic regression models.Result:Overall,98patients (51.9%) had a BMI of<25kg/m2,71(37.6%) had a BMI of25-29.9kg/m2,15(7.9%) had a BMI of30-34.9kg/m2, and4(2.1%) had a BMI of>35kg/m2. The preoperative PSA level was1.4-172.8ng/mL (mean17.6, median16.1).72patients (38.1%) had a biopsy Gleason score of<6. In score7group,3+4had36(19.0%) vs.4+3had40(21.2%),and40(21.2%) had a biopsy Gleason score of≥8(21.2%. Most patients had clinical Stage T1c (81.4%). The prostate volume was7.18cm3-91.65cm3(mean33.6cm3, median31.2cm3). ECE was reported in56patients (29.7%), SVI in24(12.7%), and LNI in8patients (4.3%).Data stratified according to BMI category revealed that preoperative blood PSA levels and prostate volume were the only two cancer-related variable that was significant statistically in patients with a BMI>35kg/m2compared with patients with a lower BMI (analysis of variance, P<0.05). The lack of effect of BMI on other PCa characteristics, like age, clinical stages, Gleason score of biopsy specimens and RP specimens and rate of extracapsular extension, seminal vesicle invasion, lymph node invasion. Furthermore, we examined the correlation of these variables with BMI, and found that elevated BMI correlated with greater prostate volume and lower PSA level. On multivariate analysis, both continuously coded and categorically coded BMI was unrelated to the rate of extracapsular extension, seminal vesicle invasion, and lymph node invasion.Conclusion:We need to consider the impact of obesity to PSA levels when we screen prostate cancer in obese people. For the enlargement of prostate in obese people, it is more inclined to misdiagnosis in biopsy. To some extent, our findings provide evidence that being overweight or obesity of any degree does not predispose to unfavorable pathologic characteristics or to an elevated PSM rate. Thus, overweight or obese individuals should be given the same treatment considerations as their nonobese counterparts.