The Diffusion Tensor Imaging Characteristics Of Multiple System Atrophy Patients And Clinical Analysis

Objective:Research the diffusion tensor imaging characteristics of MSA patients and the correlation of its clinical characteristics and magnetic resonance.Methods:We chose20cases meet diagnosic criteria for MSA as case group, acquisition of its clinical data and20healthy volunteers as control group, then made them do DTI. Then measuring the ADC values and FA values of the cases group and the control group in medulla oblongata, inferior olivary nucleus, album cerebelli, middle cerebellar peduncle, brachium pontis, superior cerebellar peduncle,pons, black substance, putamen, globus pallidus, caudate nucleus,anterior limb of internal capsule, genu of internal capsule, posterior limb of internal capsule, genu of corpus callosum, body of corpus callosum,splenium of corpus callosum and cerebral white matter. And doing t-test. At the same time using UMSARS scale to assess the clinical symptoms of MSA. After that analysising the correlation of the ADC values, the FA value of the statistically significant parts and UMSARS scale and the course of disease. Last, comparing of MSA patients with normal nerve fibers arrangement visually through3d reconstruction (DTT).Results:(1) The ADC values of medulla oblongata, inferior olivary nucleus, talbum cerebelli, middle cerebellar peduncle, pons, black substance, putamen, globus pallidus, genu of corpus callosum, cerebral white matter of case group were significantly higher than the control group. The FA values of inferior olivary nucleus, atlbum cerebelli, middle cerebellar peduncle, pons, superior cerebellar peduncle, black substance, putamen, anterior limb of internal capsule, genu of internal capsule, posterior limb of internal capsule of case group were significantly lower than the control group.(2) MSA with UMSARS scale of the score and severe disease degree, clinical amanifestations were positively correlated. The ADC values of inferior olivary nucleus were related with UMSARS scale assembly, and had nothing to do with Parkinson’s disease symptoms. The ADC values of oblongata,, talbum cerebelli, middle cerebellar peduncle, pons, black substance, putamen, globus pallidus with the contents of the UMSARS and the total scores of UMSARS scale were into positive correlation.The ADC values of genu of corpus callosum, cerebral white matter with the scales were not display correlation. The FA values of inferior olivary nucleus, atlbum cerebelli, middle cerebellar peduncle, pons, black substance, putamen, anterior limb of internal capsule, posterior limb of internal capsule with the contents of the UMSARS and the total scores of UMSARS scale were into negative correlation. The FA values of superior cerebellar peduncle and genu of internal capsule, were not display correlation.(3) DTT could visually display normal nerve fiber closely-arranged, orderly and going do smooth. The nerve fibers of patients in serious condition showed disorders, sparse, serious fracture. But lesions lighter patients’ fiber did not change obviously.Conclusions:(1) Based on the ADC values and the FA values measurement of certain parts of the brain SCA2diagnosis can be supported effectively, among them with the most accurate measurement in the inferior olivary nucleus, atlbum cerebelli, middle cerebellar peduncle, pons, putamen.(2) UMSARS rating scales can reflact the Severity and duration of disease.(3)The DTI imaging characteristics of MRA and UMSARS rating scales have good correlation, and both combined application can assist disease diagnosis and assess about illness.(4) DTI can indirectly reflect the MSA pathological changes and indirect observe the integrity of the nerve fibers, and DTT can directly observedfiber beam direction and integrity.