Development Of TCM In-situ Gel For Dermal Administration

A with the effect of anti-inflammatory, analgesia and activating blood is extracted from several Chinese traditional medicines (CTM). In clinical, A is usually administered on skin to reduce pain or swelling caused by articular cartilage damage. In-situ gel as a novel drug delivery system acts as liquid before occurring sol-gel transition on administration site. Sol-gel transition is based on several factors (e.g., temperature, pH or ionic concentration). In-situ gel is widely used on ocular, nasal and vaginal drug delivery system because of long-term effect and convenience to patients. Poloxamer407(a PPO-PEO-PPO block copolymer) has the property of biocompatibility and thermo-sensitivity, so it is widely used as thermo-sensitive gel matrix.In this study, the thermo-sensitive characteristic of Poloxamer407and the effect of addition on gelation temperature (Tg) was investigated. The result shown the Tg reduced as the concentration of Poloxamer407increased. The ethanol, PEG, HPC, and PG (at low concentration) could increase Tg of Poloxamer407solution, while DMSO shown opponent result. A new in-situ gel for dermal administration was developed in this study. The novel in-situ gel system occurred sol-gel transition on the surface of skin. Azone as a transdermal enhancer in this system can significantly increase the accumulated transdermal flux of the marked ingredient. Moreover, the Ethanol-PG-DMSO system was screened to increase the compatibility of Azone and matrix.25%Poloxamer407,40%ethanol,5%PG,5%DMSO,3%Azone,40%A and7%H2O was determined as formulation of the in-situ gel. The pharmacodynamics research exhibited the in-situ gel in this study shown significant efficacy of anti-inflammatory, analgesia and activating blood, and aged vinegar had no significant effects.