The Clinical Research To The Association Between Acute Coronary Syndrome’s Traditional Chinese Medical Typing According To Syndrome Differentiation And EPK1/2MAPK Signal Conduction Path System

Object iveThe main purpose of this essay is to explore the association between Acute Coronary Syndrome’s traditional Chinese medical typing according to syndrome differentiation and ERK1/2MAPK Signal Conduction Path System, providing a new theoretical basis for the research into the effect of traditional Chinese medicine therapy in ACS.MethodsAll64patients with ASC correspond to examined regulations were selected to be typed into four patterns according to syndrome differentiation, which includes qi stagnation and blood stasis syndrome, internal stagnation of turbid phlegm syndrome, asthenia of blood syndrome and asthenia of yangqi syndrome. The Inflammatory response index in Peripheral Blood (PB), hs-CRP, IL-6, MCP-1, MMP-9, Visfatin and MAPK were recorded to be detected through Immune Scatter Turbidimetry, Enzyme-linked Immunosorbent Assay (ELISA), etc. The comparison result with normal control group and subsection was analyzed to investigate the correlation between Acute Coronary Syndrome’s traditional Chinese medical typing according to syndrome differentiation and ERK1/2MAPK Signal Conduction Path System.Results1. ACS traditional Chinese medicine syndrome types’ characteristic:The percentage of internal stagnation of turbid phlegm syndrome is larger than any others (39.06%), followed by qi stagnation and blood stasis syndrome (29.69%) while the proportion of asthenia of blood syndrome and asthenia of yangqi syndrome are15.63%respectively. 2. The density of hs-CRP, IL-6, MCP-1, MMP-9, Visfatin and MAPK in ACS group is significantly above the normal control group level. The discrepancy between two groups has statistics difference (P<0.05). Further observation in ACS’s subsection shows the density of of hs-CRP, IL-6, MCP-1, MMP-9, Visfatin and MAPK in AMI group increased remarkably than those in UA group, the difference has statistics difference (P<0.05). Pearson’s correlation analysis was applied to indicate that MARK in ACS group was positively correlated to of hs-CRP, IL-6, MCP-1, MMP-9, Visfatin (P<1.05).3. The density level of hs-CRP, IL-6, MCP-1, MMP-9, Visfatin and MAPK in both internal stagnation of turbid phlegm syndrome and qi stagnation and blood stasis syndrome were obviously superior to that of asthenia of blood syndrome and asthenia of yangqi syndrome as well, which indicates statistically significant. However, there is no statistics significance (P>0.05) when comparing internal stagnation of turbid phlegm syndrome with qi stagnation and blood stasis syndrome and asthenia of blood syndrome and asthenia of yangqi syndrome.Conclusion1. ACS traditional Chinese medicine syndrome types’ characteristic demonstrates that ACS asthenia in the root and sthenia in the branch Sthenia syndrome seems more common than asthenia syndrome, namely internal stagnation of turbid phlegm syndrome and qi stagnation and blood stasis syndrome. Thus, more attention is recommended to be paid in its nature than level in syndrome differentiation’s early diagnosis.2. Apparently, hs-CRP, IL-6, MCP-1, MMP-9, Visfatin and MAPK is differ from those oxidative stress marker in myocardial necrosis and hemodynamics’ changing process, which provide some useful ACS physiopathology information for predicting AS’s formation and its complicated disease in early clinic treatment effectively. Their referential value in detecting unstable plaques and predicting plaques disruption could well predict the appearance of ACS, being valuable factors in severity evaluation, prognosis judgement and follow-up records.3. MAPK might be involved in ACS’s pathogenicity by regulating the occurrence and development of Inflammatory response-the expressing hs-CRP, IL-6, MCP-1, MMP-9, Visfatin included, which leads to accelerating plaque’s instability and disruption as it is reported that ERK1/2MAPK involved in visfatin’s control over MMP-9. Therefore, there exists certain correlation between ACS and ERK1/2MAPK Signal Conduction Path System.4. AS hs-CRP, IL-6, MCP-1, MMP-9, Visfatin, MAPK and ACS’s traditional Chinese medical syndrome differentiation have some relativity, it may be regards as reference index for syndrome differentiation between sthenia syndrome and asthenia syndrome Internal stagnation of turbid phlegm syndrome and qi stagnation and blood stasis syndrome in ACS may be corresponded to severity of inflammatory response in terms of Modern Medicine. That is, the exacerbation of local-global plaque’s inflammatory response based on coronary atherosclerosis caused further deterioration in coronary artery lesions, which arisen some kind of pathological changes, like the injury of endothelium aggravated, plaque rupture, plaque’s instability accelerated and the forming of local thrombosis, etc.