Chemical Constituents From Zingiber Officinale And Siegesbeckia Orientalis

During the chemical investigations on two medicinal plants, Zingiber officinale and Siegesbeckia orientalis,32compounds including3new ones were isolated and identified. The dissertation is composed of three chapters.The rhizome of Zingiber officinale also known as ginger is one of the most popular spices and is a traditional medicine in China. Phytochemical and pharmacological reports have shown that the major bioactive constituents of ginger, the gingerols, possess the following activities:anti-platelet aggregation, anticancer, anti-oxidation and others.21compounds were isolated from the ethanolic extract of the Zingiber officinale, mainly including [8]-gingesulfonic acid (1),[10]-gingesulfonic acid (2),[6]-gingesulfonic acid (3), shogasulfonic acids A (4),1-Dehydro-[10]-Gingerdione (5),1-Dehydro-[6]-gingerdione (6),1-Dehydro-[8]-gingerdione (7),[10]-gingerdione (8),[6]-gingerdione (9),[8]-gingerdione (10),[6]-Shogaol (11),[10]-gingerol (12), methyl-[6]-gingerdiol (13),6-hydroxyl-[6]-shogaol(14),3,5-diacetoxy-7-(3,4-hydroxyphenyl)-1-(3,4-hydroxyl-phenyl)heptane(15),1,5-epoxy-3-hydroxy-1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)heptane (16),4,5-dihydroxybisabola-2,10-diene (17), uridine (18), n-butyl-β-D-fructopyr-anoside (19),2-heptanol (20), linoleic acid (21).The plants of the genus Siegesbeckia are annual herbs widely distributed in tropical, subtropical, and temperate parts of the world.11compounds were isolated from the ethanolic extract of the Siegesbeckia orientalis, mainly including3’,4’-dedisulphatedatractyloside (1), menottoerpene glucoside (2), fructose (3), hypericin (4), n-butyl-a-D-fructofuranoside (5),2-desoxy-4-epi-pulchellin (6), quercetin (7), luteolin (8), casticin (9).8.9,10-trihydroxythymol glucoside (10), centaureidin (11).The third chapter reviewed the research progress of chemical constituents and pharmacological activities of Siegesbeckia.