| Objective To explore the expression of MTA1and E-cad genes and their significance in human non-small cell lung cancer (NSCLC).Methods Employ the real-time fluorescence quantitative polymerase chain reaction (Q-PCR) to examine the expression of MTA1mRNA and E-cad mRNA in40samples of NSCLC tissues,12samples of paracarcinoma tissues and12samples of benign lung tissues, and to evaluate the relativity of MTA1, E-cad mRNA expression and NSCLC clinical pathologic feature. Results①The average expression level of MTA1mRNA in NSCLC was higher than the paracarcinoma tissues and the benign lesions tissue (P<0.05).②The average expression level of E-cad mRNA in NSCLC was lower than the paracarcinoma tissues and less than the benign lesions tissue (P<0.05).③In NSCLC the expression of MTAl mRNA and E-cad mRNA was negatively correlated (r=-0.561, P<0.05).④There was no statistical difference in the MTAl mRNA and E-cad mRNA expression between the cancer and benign disease tissue adjacent tissues.⑤The expression of MTAl mRNA and E-cad mRNA was closely relevant to lymph node metastasis and the clinical stages (P<0.05); and had no relation with patient age, sex, smoking history, pathological types and grade of differentiation (P>0.05).Conclusion The over expression of the MTA1gene was positive correlates with invasion and metastasis of NSCLC and the loss or lack expression of the E-cad is negative correlates with invasion and metastasis of NSCLC. Both of the expression of MTAl and E-cad can work together for prognosis assessment of NSCLC. |
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