Correlation Study On Copd Quanitative Mesuement With Lung Function In Patients With COPD Assessed By64-slice Spiral CT

objective:1. Discusses the lung tissue function within the zoning and the area represents the clinical significance.2. Explore CT quantitative measurement period in bronchial for patients with COPD diagnosis and classification of provides the basis for the feasibility3. To study emphysema and lung function area of the relationship.in COPD patients.4, Analysis pixels index method and period of bronchial quantitative measurement method in the diagnosis of COPD advantages and disadvantages, and for early diagnosis of COPD provides an objective basis.Materials and Methods:1. Random collect65cases of patients with COPD in Shanxi medical university first clinical affiliated hospital,8cases are level1(mild),27cases are level2(medium),24cases ae rlevel3(severe), and6patients are level4(very severe). Perform lung function test and64-slice spiral CT scan in the same week, quantitative measure CT images of each case with pixels histogram, Divided density zonin, then analyse the correlation for the area volume ratio pneumonectomy values with lung function testing (PFT) related index, clear best division threshold;2. Use many plane reconstruction (MRP) technology at vertical level of bronchus in Tip segment on the right lung, the tip and after the part on left lung, the basal segment inferior both lobe to rebuilding its cross-section image measure each patients four airway section area (Ai), the area (Ao), and section radius (D), and section tracheal cavity radius (D); the airway walls section area and section of the ratio of the total area (WA%)[WA%=(Ao-Ai)/Ao], airway wall thickness and section radius ratio (TDR)[TDR=(D-D)/D]. WA%, TDR ratio analysis and PFT index of relevancy.3. Analyse the relationship of patients with COPD between the results of bronchial walls at all levels for measurement and the areaof pulmonary emphysema, normal lung density area, higher density.Results:-930HU as the threshold for area A, The Correlation between pulmonary function index are best. FEV1/FVC (r=0.685, p<0.01, N=65), FEV1%(r=0.616, p<0.01, N=65), GREAD (r=0598., p<0.01, N=65), FEF25%-75%(gamma=0.556, p<0.01, N=65);-750HU As the threshold for area B, The Correlation between pulmonary function index are best FEV1/FVC (r=0.650, p<0.01, N=65), FEV1%(r=0.555, p<0.01, N=65), GREAD (r=-0.526, p<0.01, N=65), FEF25%-75%(r=0.512, p<0.01, N=65). The correlation between the date bronchise of Under leaves basal segment right lung and thelung function index are best.Conclusion:1, patients with COPD inspiratory phase cases for best division (1023Hu-930Hu),(930Hu,-750Hu),(750Hu-200Hu);2, the bronchial wall thickness measuring and calculation method are better then measuring and calculating a bronchial section area methods, right after the leaves basal segment airway walls of lung function best reflect, double lung average airway walls of lung function reflection degree is better also;3, patients with COPD measure pixel index method and period of bronchial measuring method of COPD clinical diagnosis has certain complementary to each other.