Correlation Of Serum OPG Levels And Coronary Artery Disease Severity And Studying Of Atorvastatin Statin Intervention Effect

Objective:①To analyses the relationship between the levels of serum osteoproteger (OPG), hyper sensitive C reactive protein (hs-CRP) and severity of coronary artery lesions.②Before and after Coronary heart disease patients taking atorvastatin, serum osteoproteger (OPG) and high sensitivity C-reactive protein (hs-CRP)change in the level.Methods:According pathogenetic condition,60cases of patients with CHD were divided into acute coronary syndrome groups (ACS)(30cases), stable angina pectoris groups(SA)(30cases)and control groups (CO)(10cases), the level of OPG and hs-CRP in serum were detected with enzyme linked immunosorbent assay way. the difference of expressiving and the resulting coronary angiography were contrasted. All patients were given atorvastatin calcium (20mg/day). after two weeks, the three groups of patients with expression levels of serum of OPG and hs-CRP was detected again.And analyze the differences in the levels of expression before and after drug delivery.Result:①The levels of Serum OPG and hs-CRP were significantly higher in ACS group than those in SA group and controls group (P<0.01). The levels of Serum OPG and hs-CRP was higherin SA group than the CO group (P<0.01). As the numbers o f diseased vessels increased, there was a significant increasing in serum OPG and hs-CRP levels (P<0.01).②A positive relation was found between OPG and hs-CRP (r=0.875, P<0.01). After two weeks of taking atorvastatin calcium, serum OPG and hs-CRP in patients with ACS significantly decreased, there are statistically significant (P<0.05). The decreasing of serum hs-CRP have also statistically significant in SA group,serum OPG levels decline in the SA group, but the changes was not statistically significant (P>0.05); the changes of serum OPG and hs-CRP were not statistically significant in control group.Conclusion:The levels of serum OPG and hs-CRP are associated with the stenosis degree of the coronary artery in patients with acute coronary syndrome. OPG system were involved in the process of coronary atherosclerotic lesionsmay through interfereing with vascular inflammation reaction. Atorvastatin calcium significantly reduces the serum of OPG and hs-CRP levels of patients with ACS.