The Clinical Application Of Anti-cyclic Citrullinated Peptide]and Rheumatoid Factor In Rheumatoid Arthritis Patients

Objective To analyze the significance of anti-cyclic citrullinated peptide (CCP) antibodies and rheumatoid factor (RF) in the diagnosis and disease activity of rheumatoid arthritis (RA) patients. Methods53RA patients and178other connective tissue diseases (CTD) patients were enrolled in this investigation. We recorded the clinical datas, such as the number of swollen joints and tender joints, joint deformity, course of disease, blood test, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-CCP antibodies, RF and X-ray photograph of hands and so on. The sensitivity and specificity of anti-CCP and RF were calculated. The significance of anti-CCP antibodies in other CTD patients was explored and the association between anti-CCP antibodies, RF and inflammatory markers, clinical manifestations, course of disease and simplfied disease activity index (SDAI) were analyzed. Results The sensitivity and specificity of anti-CCP antibodies in RA patients were84.9%,98.9%; The specificity of both anti-CCP antibodies and RF positive was increased. No significant correlations were found between the level of anti-CCP antibodies and CRP, ESR, mean platelet volume (MPV), the number of swollen joints, the number of tender joints, course of disease and SDAI. The level of RF was positively correlated with SDAI. The longer the course of disease was, the higher proportions of anti-CCP positivity, RF positivity, bone erosion and joint deformity were. Conclusion The sensitivity of specificity of anti-CCP antibodies in RA patients were excellent. The specificity of both anti-CCP antibodies and RF could be promoted. As the level of RF was positively correlated with SDAI, RF could be used for the evaluation of disease activity.