| Objective:To evaluate the validity of cardiac output measurement with the modified carbon dioxide Fick (mCO2F) method, mechanical ventilated and critically ill patients with unstable hemodynamics were studied and analyzed. Compared with the cardiac output results of the patients that using invasive Swan-Ganz pulmonary artery catheter (PAC) method and pulse indicated continuous cardiac output (PiCCO) method as well as mCO2F method, correlation analysis of the three was illustrated.Methods:All34mechanical ventilated and critically ill patients were divided into two groups. In the state of complete sedation when cardiac output measured,9patients using mCO2F method (Qmco2F) and PAC method (QPAC) simultaneously, while the rest25measured with mCO2F method (Qmco2F) and PiCCO method (QPiCCO)-When steady state was reached, Qmco2F was measured, being compared with QPAC and QPiCCO at Oh and4h moment respectively. Gas analysis was also performed to central venous blood samples and mixed venous blood samples simultaneously obtained in the monitoring when cardiac output was measured with PAC method.Result:Significant coherence was observed between Qmco2F and QPAC, QmCO2F and QPiCCO-There was no statistical difference in partial carbon dioxide pressure (PCO2) between central venous blood samples and mixed venous blood samples (p>0.05), with good correlation found in PCO2from two different venous samples at Oh and4h moment (r=0.780;0.696, p<0.05). Correlation between Qmco2F and QPAC at two moment was observed as (r=0.939;0.908, p<0.01) and correlation between Qmco2F and QPiCCO (R=0.791;0.745, p<0.01).Conclusion:There was good correlation between cardiac output measurement using mCO2F method and thermodilution techniques, which suggest that cardiac output can be reliably measured in mechanical ventilated patients using mCO2F method. And this method may be cost-effective with no risk of additional morbidity or mortality. |
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