The Clinical Observation Of Dezocine In The Prevention Of Emergence Agitation In Children

Objection：To study the effectiveness and security of dezocine on the prevention ofemergence agitation under TIVA after adenotonsillectomy in children.Methods：Between August2011and Decembor2011, patients undergoing electiveadenotonsillectomy from ear-nose-throat department of the second hospital of Jilinuniversity were selected. After the inclusion and exclusion criteria screening,60patients left,who were randomly devided into experimental group and control group. Patients of twogroups received the same preanesthetic preparation, anesthetic induction and anestheticmaintence. Patients of experimental group were administered intravenously0.1mg/kgdezocine15min before the end of surgery. Patients of control group were administeredintravenously the equivoluminal normal saline15min before the end of surgery. NIBP, ECG,HR, SpO2, PETCO2and BIS were monitored continuously during the surgery. Duration ofsurgery, the time between drug withdrawal and decannulation, the score of modified Aldreteat the moment of arriving at PACU and the time of staying at PACU were recorded. Within30min after arriving at PACU, the scores of PAED and modified CHEOPS were assessedevery10min.Incidence and severity of adverse reaction such as nausea and vomiting,respiratory depression, sleepiness and itchy skin were assessed within6h after surgery. Therecords were processed with statistical analysis between two groups.Results：There was no significant differences between the two groups in the patientgeneral characteristics, duration of surgery, the time between drug withdrawal anddecannulation, the score of modified Aldrete and the time of staying at PACU(P＞0.05). Thescore of PAED at the moment of arriving at PACU and10min after arriving at PACU inexperimental group were significantly lower than those in control group(P＜0.05). Therewas no significant differences between the two groups in the score of PAED20min and30min after arriving at PACU(P＜0.05). The score of modified CHEOPS at every timepoints in experimental group were significantly lower than those in control group(P＜0.05).The incidence of nausea and vomiting within6h after surgery was higher than that in control group, however, there was no significant differences between the two groups in that (P＞0.05). There was no incidence of other adverse reaction within6h after operation betweentwo groups.Conclusion：Administering intravenously0.1mg/kg dezocine15min before the end ofsurgery is effective on the prevention of emergence agitation in children with nondelayingrevive and decannulation time and low incidence of adverse reaction. In consequence,dizocine applied to pediatric anesthesia is safe.