Blood Glucose Levels Of Diabetic Mothers And Cord Blood Leptin Of Infants And The Level Of T Cell Subsets:an Association Study

Objective：To study the expression of umbilical cord blood leptin and T cell subsets levelsin infants of diabetic mothers, and to investigate the impacts of controlling the bloodglucose concentration on the neonatal cord blood leptin and T cell subsets in diabeticpregnancy.Methods：89infants of the experiment group: pregnant women with poor glycemiccontrol in infants of diabetic mothers(A group),pregnant women with good glycemiccontrol in infants of diabetic mothers(B group),normal full-term neonates(C group),enzyme-linked immunosorbent assay was performed to determine cord blood leptinand flow cytometry for T lymphocyte subsets.Results：(1) Group A of umbilical cord blood leptin levels for the (16.6±5.4) ng/mL,group B (13.5±5.0) ng/mL, group C (13.0±3.7) ng/mL, group A compared withgroup B and group C, P＜0.05; group B compared with group C, P>0.05. Group Aof birth weight for the (3.6±0.3) kg, group B (3.4±0.4) kg, group C (3.3±0.4) kg,group A compared with group B and group C, P＜0.05; group B compared withgroup C, P>0.05.(2) In Group A, CD3was63.0±11.7, CD431.7±9.8, CD821.2±4.3, CD4/CD81.6±0.2; In Group B, CD3was55.3±3.9, CD437.0±6.0, CD820.2±5.6, CD4/CD81.9±0.3; In Group C, CD3was55.0±8.1, CD436.4±5.3, CD819.1±3.9, CD4/CD82.0±0.2. Group A compared with group B and group C, CD3, CD4, CD4/CD8were statistically significant, P <0.05, CD8was not statistically significant, P>0.05;group B compared with group C, CD3, CD4, CD8, CD4/CD8were not statisticallysignificant, P>0.05.(3) The level of leptin of the male newborns was significantly lower than that offemale newborns(P<0.05); no statistical significance was found in weight between these two groups(P>0.05).(4) The level of CD4、CD4/CD8of the male newborns was significantly lowerthan that of female newborns(P＜0.05); no statistical significance was found inCD4/CD8between these two groups(P>0.05).Conclusions：(1)Leptin levels in infants of diabetic mothers are higher than that of normalnewborns;(2) The leptin level in infants of diabetic pregnant mothers who have a goodcontrol in blood glucose is lower than those of poor glycaemic control.(3)Umbilical cord blood leptin levels are positively correlated with neonatalbirth weight;(4)The CD4、CD4/CD8level in infants of diabetic mothers is decreasedsignificantly;(5) The CD4、CD4/CD8level in infants of diabetic pregnant mothers who havea good control in blood glucose is higher than those of poor glycaemic control.(6)The level of leptin and T cell subsets of the male newborns was significantlylower than that of female newborns.