Vascular Endothelial Growth Factor Polymorphisms And The Risk Of Endometriosis:a Mata Analysis

Objective To analyze the potential association between the single ucleotide polymorphisms (SNPs), haplotypes of the vascular endothelial growth factor (VEGF) gene and the risk of developing Endometriosis by meta-analysis.Methods Published case-control studies about the influence of VEGF polymorphisms on endometriosis were searched and screened in Medline, PubMed, the Cochrane library, China National Knowledge Internet (CNKI),Chinese Biological Medicine Disk (CBM), data base of Wanfang and Foreign Medical Journal Full-Text Service (FMJS). RevMan5.1software was used for meta-analysis.Results Finally nine literatures including1610endometrisis patients (endometriosis) and1643controls (non-endometriosis) were eligible to the criteria. To investigating the VEGF gene loci about-460C/T,+405C/G,+936C/T,-2578C/A and-1154G/A. The results of meta-analysis showed: there was no evidence for association between endometriosis and the VEGF-460C/T,-2578C/A and-1154G/A SNPs in the genotype or allele frequencies distribution (P>0.05). Significant differences were found in the frequencies distribution of VEGF+405CC genotype [P=0.009, OR=1.45,95%confidence intervals (CI):1.10-1.91] and C allele (P=0.020, OR=1.19,95%CI:1.03-1.38) and G allele (P=0.020,OR=0.84,95%CI:0.72-0.97). Also the+936CC genotype (P=0.050,OR=0.81,95%CI:0.66-1.00) and C allele (P=0.040, OR=0.93,95%CI:0.70-0.99) and T allele (P=0.040,OR=1.20,95%CI:1.01-1.43). A lack of association was found between the-460C/T and+405C/G haplotypes (P>0.05).Conclusion The VEGF+405C/G and+936C/T SNPs are associated with the risk of endometriosis. Women carrying the+405CC genotype or+405Callele or the+936T allele could significantly increase the risk of developing endometriosis.