| Purpose To investigate the pathogenesis of single lacunar infarction in patients within the perforator territory of MCAMethods A total of90patients with lacunar infarction in the perforator territory of MCA within48hours of stoke onset admitted between March2011and December2012at the Second Affiliated Hospital of Chongqing Medical University, Department of Neurology. We divided the lacunar into3groups according to lesion location and the presence of parent artery disease:(1) lacunar with MCA disease,(2) proximal lacunar without MCA disease,(3) distal lacunar without MCA disease. The prevalence of SVD indicators (leukoaraiosis and enlarged perivascular spaces) and atherosclerosis indicators (cerebral atherosclerosis and coronary heart disease) were compared among the groups.Results Lacunar with MCA disease had the highest prevalence of atherosclerosis indicators and the lowest prevalence of SVD indicators, whereas distal lacunar without MCA disease had the lowest prevalence of atherosclerosis indicators and the highest prevalence of SVD indicators. Proximal lacunar without MCA disease showed intermediate features.Conclusion Differences in SVD and atherosclerosis indicators suggest that lacunar infarction within the perforator territory of MCA has a heterogeneous pathogenesis according to lesion location and the presence of PAD... |
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