The Relationship Between Serum Uric Acid Level And Metabolic Syndrome And Its Various Components

1.BackgroundMetabolic syndrome (MS) and hyperuricemia (HUA) is an important risk factor for cardiovascular disease. In recent years, related researches of the relationship on the metabolic syndrome and hyperuricemia and clinical outcomes are made in the international.however, there are still a lot of questions on the relationship between hyperuricemia and metabolic syndrome. Along with the raising of our country economy and the changes of people’s life style, the prevalence of hyperuricemia and metabolic syndrome obviously increases,unfortunately, for China’s crowd, there is not systematic and standard research. So this is the foothold of our research,and provide direct evidence for the relationship between metabolic syndrome and hyperuricemia.2.Objective(1) the potential value of blood uric acid levels as a marker of metabolic syndrome.(2) discusses the relationship between the change of blood uric acid levels and metabolic syndrome and its related components.3.MethodsAcross-sectional study was conducted from June2007to May2008in Jinan city, Jining city, Zibo city and Taian city, Shandong province. We selected randomly303groups in the study, including male136(44.88%), female167(55.12%), the average age is50.14±10.9years old. All respondents are voluntary, and signed informed agreement, and inquired by taking unified questionnaire investigation, made physical examination and laboratory tests. The diagnostic criteria for MS uses CDS standards.The diagnosis standard of hyperuricemia: male blood uric acid levels>420μ mol/L (7mg/dl, women>357μ mol/L (6mg/dl). The aim is to analysis sick characteristics of hyperuricemia、metabolic syndrome, and the relationship between hyperuricemia and metabolic syndrome or its various components. SAS9.1software used for statistical analysis. Measurable data was showed as meand±standard deviation(SD). X2test was used to compare rates. P<0.05was considered statistically significant.4.Results4.1. General situation:total in303people,136men,167women, men and women for sex ratio at0.81:1. The average age is50.14±10.9years, with men mean age is49.26±0.9years old, female mean age is50.86±10.9years old.20～29of the total population2.97%,30to3911.88%,40to4933.99%,50～5933.00%,60～6912.54%,70～795.28%,80～890.33%.4.2. Hyperuricemia and metabolic syndrome:in hyperuricemia patients metabolic syndrome patients accounted for37.68%, patients with the metabolic syndrome hyperuricemia patients accounted for34.21%, chi-square test shows that the metabolic syndrome risk and hyperuricemia exists correlation. Increasing with age, the prevalence of hyperuricemia and metabolic syndrome are elevated. In the hyperuricemia patients, metabolic syndrome risk increases with age.4.3. Hyperuricemia and high blood pressure, high blood glucose rate:hyperuricemia patients with hypertension is the incidence of57.97%; hyperuricemia patients with high blood glucose is the rate of15.94%. Whether or not hyperuricemia is related with high blood glucose and high blood pressure chi-square test showed a statistically significant difference.4.4. The hyperuricemia and obesity, high blood lipids:incidence of hyperuricemia in patients with BMI>25incidence rate of71.01%; wherein the waist circumference greater than85CM male high uric acid in male patients with incidence of90.91%, waist circumference greater than80cm females account for high uric acid in female patients with incidence of80%; hyperuricemia patients fasting TG greater than1.7mmol/l the incidence of53.62%; hyperuricemia patients fasting HDL-C men less than0.9mmol/L occurrence rate is0, the female is less than1.0mmol/L rate was0. Serum uric acid levels in normal and hyperuricemia and obesity, high blood lipids, the differences were statistically significant. 4.5. Analysis of variance shows that there was a statistically significant difference between the level of serum uric acid and wais、WHR. In the male youth group, analysis of variance shows that there is a statistically significant difference between the level of serum uric acid and HDL-C; in the male middle-aged groups, analysis of variance shows that there is a statistically significant difference between the level of serum uric acid and FAT、waist; in the male elderly group, analysis of variance shows that there is a statistically significant difference between the level of serum uric acid and FPG, FAT, waist.4.6. Analysis of variance shows that there is a statistically significant difference between the level of serum uric acid and SBP. in the female middle-aged groups, analysis of variance shows that there is a statistically significant difference between the level of serum uric acid and SBP; in the female elderly group, analysis of variance shows that there is a statistically significant difference between the level of serum uric acid and HDL-C、 WHR、microglobin.4.7. The relationship between serum uric acid level and the number of components of metabolic syndrome:in group of hyperuricemia,components of metabolic syndrome in a number of2and above is common, in the group of normal uric acid level, components of metabolic syndrome in a number of0or1is common.4.8. serum uric acid level as a marker of potential values of metabolic syndrome:Serum uric acid level can predict the risk of metabolic syndrome.5.Conclusion5.1. Hyperuricemia and metabolic syndrome components are closely related, which prompts that by detecting the concentration of serum uric acid can predict and provide the theoretical basis for early prevention of cardio-cerebral-vascular disease.5.2. Serum uric acid level can to be a marker of potential values of metabolic syndrome, serum uric acid level can predict the risk of metabolic syndrome.