Studies On The Preparation And Quality Standards Of Xiao Xian Xiong Tang Particles

Xiao Xian Xiong Tang decoction dose prescription is from "Treatise on the"in"sun identified abnormal pulse passes and Governance " chapter, the original:summary breast disease, heart is, according to the pain of, the pulse FuHua, small trapped chest Lord of soup. The traditional all have cited, the prescriptions in the modern Chinese clinical is still widely used, mainly used in the treatment of chronic gastritis, conditions such as bronchitis, curative effect is distinct.The subject of Xiao Xian Xiong Tang has a comprehensive and systematic overview both in ancient and modern clinical application, we select the dosage forms of decoction by the technical requirements of Chinese medicine formulations of drugs, preparation process, quality standards and stability were studied.Preparation:Through accessing relevant literature referencing to the physical and chemical properties, pharmacological effects and clinical applications of biological active ingredients of prescription drugs and the result of traditional and modern extraction technology comparative testing, formulate heating reflux extraction process path with water as solvent. Though single factor test and L9(34) orthogonal test, soak time and amount of water, extraction time, extraction times are investigated to determine the best extraction conditions; Through the enrichment drying experiment, with the enrichment dry pressure, temperature investigation, work out the appropriate concentration drying process conditions; Through the forming technology research, investigation of accessories, is used to make appropriate accessories and dosage. Preparation of a whole is very smooth, reasonable and stable.Quality Standards:In order to guarantee the quality of pharmacy stably and controllablly, the quality standards of Xiao Xian Xiong Tang particles is set up with the help of modern pharmaceutical technology, such as TLC and HPLC.After a series of experimental studies, the most important traditional Chinese medicine herb in the prescription was controled quantitatively, and the quality standards were established. Preparation of preliminary stability test:According to the technical requirements of "Dr-ug Registra tion", in a preliminary stability test, respectively0months,1month,2months,3months,6months,we review the character, identification, content,relative density and oth-er physiochemical index of decoction agent regulariy. The results showed that all the index-es stable are conformed to the standard and relevant provisions of decoction agent of2010version "Chinese Pharmacopoeia", good stability.