Risk Factors For Cerebral Microbleeds In Acute Cerebral Infraction Patients

Objective To detect cerebral microbleeds (CMBs) in a cohort of acute ischemicstroke patients by susceptibility-weighted imaging(SWI).Prevalence and the characterof CMBs imaging were analysised,and to evaluate risk factors for CMBs.Methods This is a cross-sectional study of82participants.Presence and number ofCMBs in consecutive acute ischaemic stroke patients admitted to our hospital fromFebruary2010to June2011were rated prospectively. All patients were examinedusing SWI and conventional Spin Echo(SE) sequence by siemens1.5T MRmachine.Patients were divided into two groups according to the presence of CMBs inSWI. Mutivariate model were generated to determine the contribution ofdemographic、clinical and biochemical variables to the presence of CMBs.All of ourfindings were checked and approved by attending physicians using the Brain ObserverMicroBleed Scale Stroke(BOMBS)to improve interrater agreement aboutCMBs.Satistical analysis was performed with the Statistical Package of SocialSceences(SPSS,inc).Results Of82patients,40(48.8%) had CMBs evident on SWI. The number of CMBsranged from1to32,which mostly located in the basal ganglia.In univariate analysis,CMBs were commonly seen in patients with history of stroke,and with the agegrowing,the presence of CMBs are also raising. total cholesterol, low densitylipoprotein cholesterol, triglycerides, plasma total homocysteine were significantlyassociated with the presence of CMBs (P=0.000,0.002,0.024,0.000respectively).In multivariate logistic regression analysis, Plasma total homocysteine was anindependent factor increasing the risk of CMBs.[P=0.003,OR=1.986,95%CI：1.125～1.754].Conclusion SWI sequence are more sensitive than SE sequence to detect CMBs,andCMBs are more frequently noted in acute ischaemic stroke patients,as well as thosewith high level plasma total homocysteine.