Observational Study Of The Relationship Between Ce_LOC And Ce_ROC Of Propofol By Using Two TCI Model

Objective:Observational study of the relationship between CeLOC, and CeROC of propofol by using Marsh model and Schnider model.Methods:Sixty male patients (ASA Ⅰ-Ⅱ), who underwent unilateral arthroscopic-knee surgery with combined spinal-epidural anesthesia, were randomly divided into two groups:Marsh group (M, n=30) and Schnider group (S, n=30). The level of sensorial block was controlled between T10and S5. The infusing speed of propofol was300ml/h until LOC under the viewer mode of Base Primea TCI workstation and then record CeLOC. After the pause of infusion, record Ce ROC. The blood pressure, heart rate and blood oxygen saturation were recorded every1.0min.Results:CeLOC was2.38±0.16,3.32±0.15μg/ml, and CeROC was0.95±0.11μg/ml,0.80±0.12μg/ml for the Marsh group and Schnider group, respectively. The pearson correlation coefficient between Ce LOC and CeROC was0.508for the Marsh group with a significance of0.005on both sides and0.621for the Schnider group with a significance of0.000 on both sides.Conclusions:Significant correlation exists between Ce LOC and CeROC under both models. Schnider model exceeds Marsh model with statistical significance. The difference between CeLOC and CeROC is statistically significant when both Marsh model (K=1.21/min) and Schnider model (K=0.456/min) are employed to predict Ce.