Risk Factors Of Short-term Relapse After Radiofrequence Ablation Completely In Hepatocellual Carcinoma

Object: To investigate the risk factors of short-term relapseafter radiofrequency ablation(RFA) completely in hepatocellularcarcinoma(HCC).Methods: The clinicopathological date of50pations with HCCundergo RFA in the first afficated hospital of Guangxi medical universityfrom the june2008to December2011.In all cases RFA was performed withpercutaneous approach under ultrasound guidance. Treatmentefficacy(recurrence) was assessed using dual phase computed tomography(CT)or (Magnetic Resonance Imaging)MRI and contrast enhanced ultrasoundwithin1to3months after RFA complete treatment. Twelve potential variablesfor short-term relapse were analyzed, including sex, age, the condition oftumor boundary,liver function child-pugh classification,the number of tumor,the size of tumor, alpha-fetoprotein(AFP)value,originating or recurrence,transarterial chemoembolization (TACE) before RFA treatment,near oraway from the big vessel, whether the tumor in special sites,hepatitis B history.Results: within1to3months after RFA complete treatment, there were36cases of HCC were not of recurrence,14cases of relapse, recurrence rate 28%. multivariate analysis: near great vessels (P=0.019) and unclear tumorboundary (P=0.041) were the independent risk factors of short-term relapseafter radiofrequency ablation completely in hepatocellular carcinoma.Conclution: Near great vessels and unclear tumor boundary were theindependent risk factors of short-term relapse after radiofrequencyablation(RFA) completely in hepatocellular carcinoma. So in eachradiofrequency ablation, the tumor should have the safe margin of ablationas far as possible in order to reduce the short-term recurrence rates of tumor.