Estimate Of Follow-up Visit And Therapies Of Urogenital Chlamydia Trachomatis Infection And Relationship Between Course Of The Disease And Vitamin D3Level

Chlamydia trachomatis is the most common pathogens of sexually transmitted disease in the world, and it is a threat to the patient’s physical and mental health.At present, the incidence is increasing evry year in the world. There are different standards of cure, and there are different opinions about if patients with Ct infection need to be followed up or not. At the same time, therapeutic method to Ct infection are not satifided enough, a lot of patients got treatment failure and delayed healing.Objective:the efficacy of moxifloxacin, minocycline, azithromycin and clarithromycin for the treatment of genitoimnaiy tract Ct infection are evaluated by different standards of cure,and we hope to find the best standard of cure and the best treatment for Ct infection.Methods:The patients diagnosed with Ct genital tract infection in Tianjin Medical University General Hospital dermatology from January2006to December2010were collected. They must conform to the following four criterias,(1) Themselves or their spouses should have non-marital sexual relations;(2) Male should have varying degrees of urethritis, female should have abnormal vaginal discharge, with or without urethral irritation;(3) They should have the genital tract Chlamydia trachomatis infection diagnosed by laboratory examination;(4) they should not be effected by neisseria gonorrhoeae, Mycoplasma, Candidain. These patients were treated by oral antibiotic and long-term follow-up. The standard of Clinical cure is that symptoms of patients disappear; the male do not have urethral discharge, dysuria, the female abnormal vaginal discharge disappears.1week,5weeks,9weeks after treatment,Ct should be detected by laboratory examination separately;if the results were negative,we can think it is cured, positive for the not cured. All data should undergo χ2test(P<0.05) by SPSS10.0Results:The clinical cure rate of rateazithromycin, minocycline, moxifloxacin, clarithromycin were88.91%,84.85%,74.88%,72.89%.1week,5weeks,9weeks after the treatment,the cure rates of azithromycin, minocycline, moxifloxacin, clarithromycin were78.91%,73.28%,71.56%;69.16%,63.53%,62.88%;87.68%,84.00%,83.41%;85.51%,79.44%,77.57%, and we found the significant difference between5,9weeks review and1week review, so the follow-up should be at one week and five weeks after the the end of treatment of Ct. The results of the clinical cure standard and the etiology cure standard are different.Azithromycin, moxifloxacin, clarithromycin etiology cure rate has decreased year by year, while the cure rate of minocycline is more stable.Conclusion:The antibiotic treatment of genitourinary tract Chlamydia trachomatisi nfection should be followed up after treatment, the standard of clinic cure should be combined with the standard of etiological.The laboratory examination of Ct should be taken in one week and five weeks after treatment. According to the standard of the clinical cure rate from high to low,we can arrange as azithromycin, minocycline, moxifloxacin, clarithromycin.According to the standard of the etiological cure rate from high to low we can arrange as moxifloxacin,clarithromycm, azithromycin minocycline. Because of different cure rates, so we can uesd them together, if Ct is difficult to cure.