Experimental Study Of Simiaojunyi Ointment On Anorectal Postoperative Pain Model In Rats Serum TNF-a, IL-6and IL-10Affect

Objective:In this study, Simaojunyi ointment anorectal postoperative pain model in rat serum analgesic substance IL-10, the pain caused by substances TNF-a, IL-6from the microscopic and molecular level, to explore the Simaojunyi ointment treatment of anorectal postoperative pain analgesic mechanism.Method:Healthy SD rats40, were20male and20female, were randomly divided into normal group, model group, Simaojunyi ointment and tetracaine hydrochloride glue group. In addition to the normal group, the rats in each group to establish anorectal postoperative pain model, Successful modeling, in addition to the normal group, model group, were given Simaojunyi ointment incision Simaojunyi ointment dressing, the dressing of tetracaine hydrochloride glue group incision tetracaine hydrochloride mortar, After3days of treatment, blood processing measured using enzyme-linked immunosorbent assay in serum TNF-a, IL-6and IL-10content changes.Results:Anorectal postoperative pain model in rats serum TNF-a, IL-6levels were significantly increased, IL-10decreased significantly compared with the normal group (P<0.01):Simaojunyi ointment make rats serum TNF-a, IL-6content was significantly lower, IL-10content increased significantly, three return to a normal level, its improve anus bowel disease postoperative pain can also be related to this; compared with model group (P<0.01):Carmel, Simaojunyi ointment, tetracaine hydrochloride mortar group close to the normal control group, no significant difference (P>0.05).Conclusion:Simaojunyi ointment can significantly improve anorectal postoperative rats pain, reduce the Anus postoperative pain model of serum TNF-a, IL-6levels, elevated IL-10levels so as to achieve pain purpose, which may regulate pain factor, and treatment of anorectal pain in rats after one of the mechanisms, it is worth further study.