| [Objective]Explore the benevolence of Renzhu Jianwei decoction in treatment of chronic atrophic gastritis with clinical efficacy and mechanism of Qi-deficiency and blood stasis-heat syndrome.[Methods]Renzhu Jianwei decoction in treating blood stasis due to Qi deficiency-heat syndrome of chronic atrophic gastritis30Cases, and30Dimensional control groups in clinical and pathological effects of enzyme in comparison.3months for a course, taking a course.[Result]1. Effect of clinical symptoms and signs:treatment can significantly improve stomach swelling, main manifestations dull pain, pain in the stomach, belching, anti-acid, noisy, constipated, and other symptoms, the curative effect is significantly better than the control group (P<0.05), and is satisfied that the change of no obvious difference, loose stool symptoms (P>0.05).2. Therapeutic effect of endoscopic:endoscopic improvement of gastric mucosa in the treatment group than in the control group (P<0.05).3.Pathologic effects:the treatment group is bettet than the control group in improving atrophy and intestinal metaplasia (p<0.05);two groups are no significant difference in efficacy in the dysplasia (p>0.05).4. Renzhu Jianwei decoction Is not a significant adverse reaction in clinical application.[Discussion]Through statistical analysis,.show that benevolence of Renzhu Jianwei decoction CAG Both good clinical efficacy, significantly reversing precancerous lesion of atrophic gastritis pathologic States to further elaborate on the benevolence of Renzhu Jianwei decoction is treated CAG Effective formulas, and prompted its action mechanism may be related Antioxidation and scavenging free radicals, and excessive cell proliferation and inhibition to kill Hp,induce, promote cell differentiation and maturation; inhibits the inactivation of tumor suppressor gene and oncogene activation; regulation of serum nitric oxide (NO) levels enhances gastric mucosal blood circulation effects. |
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