Oral Cryotherapy In Prevention Of Oral Mucositis In Patients Receiving Myeloablative Hematopoietic Stem Cell Transplation:a Clinical Research

[Object] The purpose of this study is to investigate the effect of oral cryotherapy in prevention of oral mucositis in patients receiving myeloablative hematopoietic stem cell transplation, to explore the effect of different time of using method of oral cryotheapy and different oral cryotheapy duration., as well as to find a path of clinical oral nursing for the patient of HSCT.[Method] This study is a prospective random clinical study, which involves voluntary37patients, who come from the bone marrow transplantation unit of the First Affliated Hospital of Suzhou University. With the basic oral nursing, the objects of the study are divided into study group and control group depending on whether using the method of oral cryotheapy or not. Meanwhile, decide on the best opportunity of oral cryotheapy intervention according to pharmacokinetics and phase of drug elimination. Study group are divided into no.1(Using oral cryotheapy from the very beginning of drug infusion) and no.2(Using oral cryotheapy half way of drug infusion). Then analyze and compare the data by spss15.0.[Result]①According to the National Cancer Institute-Common Toxicity Criteria and WHO Mucositis Grading, the rate of mucositis is49.67%in study group one,47.69%in study group two, and54.33%in control group, the results of the three group are not statistically different(P<0.05).②Shorten duration of oral cryotherapy has a good effect on preventing severe oral mucositis caused by myeloablative therapy.③There are statistically significant differences in terms of group in the fact of media lasting time of oral mucositis(X2=8.075,P=0.018<0.05).④Oral mucositis can easily occur at cheek(43.9%)、tongue(27.57%)etc.⑤Oral cryotheapy can’t improve the oral comfort level of the renal transplant patients very well. During the period of myeloablative therapy, as the drug using time extends, the uncomfortable feeling of the HSCT patients is more severe in study group one.⑥Shorten duration of oral cryotherapy can especially improve patients’uncomfortable symptoms in stomach and intestine while they are in the period of myeloablative therapy, such as reducing the frequency of nausea and vomit.[conclusion]①Our findings have demonstrated that oral cryotherapy can reduce oral mucositis which caused by the myeloablative therapy.②To the HSCT patients, while using oral cryotheapy, we should pay great attention to the time and duration.