Study Of Relationship Between Circulating Levels Of Growth Differentiation Factor15and Seveirty Of Coronary Heart Disease

Objective:The relationship between circulating levels of growth differentiation factor15(GDF15) in patients with coronary heart disease and severity of coronary heartdisease was investigated.Methods:From April2011to January2012,92patients with coronary heart disease and20control group members were enrolled in the study. After the physical andbiochemical examinations, the circulating levels of GDF15were measured byELISA with the peripheral venous blood samples of patients on admission within24hours. Patients were grouped by their clinical types, the number of diseased vesselsand the severity of coronary atherosclerosis. GDF15, Lp(a), BaPWV and IMT werecompared among the groups. GDF15, Lp(a) and related indicators were analyzedwith Gensini score by univariate analysis, the proved indicators were promoted withmultiple linear regression analysis.Results:(1)GDF15, Lp(a), BaPWV and IMT in the four groups were statisticallydifference regardless of which grouping. The difference was more meaningful asgrouped by GDF15. With the higher Gensini score of coronary heart disease or morediseased vessels, the circulating levels of GDF15were highly elevated.(2)Age, GDF15, Lp(a), BaPWV, IMT and Gensini score of coronary heartdisease were positively correlated, HDL and Gensini score were negatively correlated.The correlation coefficient of GDF15and Lp(a) were0.694and0.619. GDF15andLp(a) may be risk factors for coronary heart disease, and HDL may be one of theprotective factors for coronary heart disease.Conclusions:The circulating levels of GDF15in patients with coronary heart disease and theseverity of coronary heart disease are positively correlated, and the GDF15may be anrisk factor for coronary heart disease.