A Genome-wide Association Study On Sporadic Parkinson’s Disease Of Chinese Han Population Identifies Susceptibility Loci

Objective：To screen SPD associated SNPs in Chinese Han population andindentify susceptibility genes/loci for SPD by using GWAS approach.Methods： Collect the clinical material and peripheral venous blood of SPD andhealthy adults, establish the DNA pools then screen the SNPs using HumanOmniZhouhua8chip, analysis the susceptibility genes and the possible pathogenicpathway by sifting the positive SNPs of SPD.Results：1、27796gene mutation difference between the groups are statisiticallysignificant from all the positive SNPs loci screened, compared with the common genemutation sites differences of gene chip；2、positive SNPs loci (rs12526148、rs9365352、rs1478370) were found verified the susceptibility gene PARK2andSNCAIP of PD again；3、 the gene loci(rs9480677、rs6054529、rs2005292、rs6924228、rs13329408、rs12648062、kgp3105958、kgp1313361) in ATG5、FOS、BMP2、GCLC、IGF1R、IGFBP7、TXNRD2、XKH genes are associated with agingand autophagy through pathways analysis.Conclusions：1、verity the susceptibility gene PARK2and SNCAIP of PD；2、the gene loci of aging and autophagy may be involved in the pathogenesis of SPD.